Results 181 to 190 of about 29,799 (296)

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Robustness to model misspecification in Bayesian experimental design

Scientific experiments can be costly to conduct due to various reasons. Therefore, researchers need to choose the experimental design which allows them to obtain the highest amount of information possible. As an information-theoretical framework based on
Ulukir, Behram
core   +1 more source

Calibrated Model Criticism Using Split Predictive Checks. [PDF]

J Am Stat Assoc
Li J, Huggins JH.
europepmc   +1 more source

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Robust discovery of mutational signatures using power posteriors. [PDF]

PLoS Comput Biol
Xue C, Miller JW, Carter SL, Huggins JH.
europepmc   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

DOMAIN-AWARE MATRIX COMPLETION FOR PHENOTYPE IMPUTATION USING ELECTRONIC HEALTH RECORD DATA WITH APPLICATIONS IN GENOMIC RESEARCH. [PDF]

Ann Appl Stat
Wu H, Lee CH, Abiri N, Ionita-Laza I.
europepmc   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

Spatial observation‐error correlations for AMSU‐A in all‐sky assimilation: An ECMWF and UK Met Office intercomparison

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Assimilation of AMSU‐A all‐sky observations can be increased up to fivefold if spatial observation‐error correlations are accounted for properly. New correlation estimates derived using data from ECMWF and the UK Met Office reveal that correlation length‐scales are between 75 and 150 km for AMSU‐A channels peaking in the troposphere. This is attributed
Rishabh Bhatt, Massimo Bonavita, Niels Bormann, Sarah L. Dance, Alison Fowler, Elías Hólm, Christopher J. Merchant, Jonathan Mittaz, Stuart Newman, Joanne Waller   +9 more
wiley   +1 more source

Robust Estimation of Polyserial Correlation Coefficients: A Density Power Divergence Approach. [PDF]

Psychometrika
Welz M.
europepmc   +1 more source