Results 141 to 150 of about 17,373 (263)

Mirikizumab pharmacokinetics and exposure–response in pediatric patients with moderate‐to‐severe ulcerative colitis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 474-485, March 2025.
Abstract Mirikizumab is a p19‐directed anti‐interleukin‐23 antibody approved for the treatment of adults with moderate‐to‐severe ulcerative colitis (UC). Here, we report the first data of mirikizumab pharmacokinetics (PK) and exposure–response (E/R) relationships in pediatric participants (aged 2 to <18 years weighing >10 kg) with moderate‐to‐severe UC
Yuki Otani, Laiyi Chua, Wendy J. Komocsar, Amy Larkin, Jordan Johns, Xin Zhang   +5 more
wiley   +1 more source

Identifiability and model misspecification for modelling recurrent infections using routine health care data. [PDF]

Am J Epidemiol
Yan AWC, Flegg JA, Poespoprodjo JR, Douglas NM, Price RN, Devine A, Price DJ, Chisholm RH.   +7 more
europepmc   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Calibrated Model Criticism Using Split Predictive Checks. [PDF]

J Am Stat Assoc
Li J, Huggins JH.
europepmc   +1 more source

Mechanistic Learning for Predicting Survival Outcomes in Head and Neck Squamous Cell Carcinoma

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 540-550, March 2025.
ABSTRACT We employed a mechanistic learning approach, integrating on‐treatment tumor kinetics (TK) modeling with various machine learning (ML) models to address the challenge of predicting post‐progression survival (PPS)—the duration from the time of documented disease progression to death—and overall survival (OS) in Head and Neck Squamous Cell ...
Kevin Atsou, Anne Auperin, Jôel Guigay, Sébastien Salas, Sebastien Benzekry   +4 more
wiley   +1 more source

The Impact of Model Misspecification on the Individual Causal Association in Surrogate Endpoint Evaluation. [PDF]

Pharm Stat
Deliorman G, Stijven F, Van der Elst W, Pardo MDC, Alonso A.   +4 more
europepmc   +1 more source

Spatial observation‐error correlations for AMSU‐A in all‐sky assimilation: An ECMWF and UK Met Office intercomparison

Quarterly Journal of the Royal Meteorological Society, EarlyView.
Assimilation of AMSU‐A all‐sky observations can be increased up to fivefold if spatial observation‐error correlations are accounted for properly. New correlation estimates derived using data from ECMWF and the UK Met Office reveal that correlation length‐scales are between 75 and 150 km for AMSU‐A channels peaking in the troposphere. This is attributed
Rishabh Bhatt, Massimo Bonavita, Niels Bormann, Sarah L. Dance, Alison Fowler, Elías Hólm, Christopher J. Merchant, Jonathan Mittaz, Stuart Newman, Joanne Waller   +9 more
wiley   +1 more source

Robust discovery of mutational signatures using power posteriors. [PDF]

PLoS Comput Biol
Xue C, Miller JW, Carter SL, Huggins JH.
europepmc   +1 more source

One Size Does Not Fit All—Ignoring Spatial Variation in Occupancy and Detectability Underestimates the Required Number of Camera Trap Sites

Remote Sensing in Ecology and Conservation, EarlyView.
Camera trap occupancy studies often rely on simple rules of thumb that assume constant occupancy and detection across sites. Using simulations, we show that accurate occupancy estimates require 10–40 sites with no spatial variation, 20–120 with simple variation and 40–600 with complex spatial structures.
Pradeep Raj Joshi, Andreas Zedrosser, Rahel Sollmann, Nuria Selva, Simone Santoro   +4 more
wiley   +1 more source

DOMAIN-AWARE MATRIX COMPLETION FOR PHENOTYPE IMPUTATION USING ELECTRONIC HEALTH RECORD DATA WITH APPLICATIONS IN GENOMIC RESEARCH. [PDF]

Ann Appl Stat
Wu H, Lee CH, Abiri N, Ionita-Laza I.
europepmc   +1 more source