Results 131 to 140 of about 17,373 (263)

Optimizing IMPULSED Acquisition Protocols for Clinical 3T Scanners Through Bayesian Experimental Design

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To optimize diffusion MRI acquisition protocols for Imaging Microstructural Parameters Using Limited Spectrally Edited Diffusion (IMPULSED) model at clinical 3T scanner using Bayesian experimental design, enabling accurate cellular‐scale parameter estimation under realistic scan time and scanner hardware constraints.
Yan Dai, Xun Jia, Todd Aguilera, Kai Jiang, Arely Perez Rodriguez, Isabelle Vanhaezebrouck, Jie Deng   +6 more
wiley   +1 more source

Optimal Designs and Inspection Time Decisions for Gamma Accelerated Degradation Tests

Naval Research Logistics (NRL), EarlyView.
ABSTRACT This study analytically derives optimal designs for gamma accelerated degradation tests while incorporating inspection time as a design variable under both D‐ and V‐optimality criteria. Under D‐optimality, we prove that the optimal design allocates test units exclusively to the lowest and highest stress levels and adopts the longest inspection
Hung‐Ping Tung, I‐Chen Lee
wiley   +1 more source

When models choose metrics: Hidden geometry in computational biology. [PDF]

PLoS Comput Biol
Fox DM.
europepmc   +1 more source

Piecewise structural equation modelling in ecology: common pitfalls and best practices for causal inference

Oikos, EarlyView.
Structural equation modelling (SEM) has become a cornerstone tool in ecology for testing hypotheses about causal relationships and disentangling direct and indirect effects. However, its growing use has led to frequent conceptual and methodological misapplications.
Álvaro Gaytán
wiley   +1 more source

A Framework for the Estimation of Quality-Adjusted Life-Years Using Joint Models of Longitudinal and Survival Data. [PDF]

Med Decis Making
Crowther MJ, Gasparini A, Ekberg S, Felizzi F, Gallagher E, Paracha N.   +5 more
europepmc   +1 more source

Beyond "No Unmeasured Confounding": Challenges and Opportunities for Cornfield-Style Reasoning in Modern Causal Inference. [PDF]

Obs Stud
Hettinger GCN, Renson A, Susmann HP, Díaz I.   +3 more
europepmc   +1 more source

Intranasal diamorphine population pharmacokinetics modeling and simulation in pediatric breakthrough pain

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 435-447, March 2025.
Abstract Intranasal diamorphine (IND), approved for managing breakthrough pain in the UK, has been identified as an acceptable alternative offering effective, expedient, and less traumatic analgesia for children. However, the current dose regimen in pediatric populations relies on clinical expertise while the pharmacokinetics properties are poorly ...
Lianjin Cai, Jingchen Zhai, Beihong Ji, Fengyang Han, Taoyu Niu, Luxuan Wang, Junmei Wang   +6 more
wiley   +1 more source

Privacy-enhancing sequential learning under heterogeneous selection bias in multi-site electronic health records data. [PDF]

J Am Med Inform Assoc
Kundu R, Salvatore M, Patel KK, Ohno-Machado L, Cho H, Shi X, Mukherjee B.   +6 more
europepmc   +1 more source

Semi‐mechanistic population PK/PD model to aid clinical understanding of myelodysplastic syndromes following treatment with Venetoclax and Azacitidine

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 448-459, March 2025.
Abstract Myelodysplastic syndromes (MDS) represent a group of bone marrow disorders involving cytopenias, hypercellular bone marrow, and dysplastic hematopoietic progenitors. MDS remains a challenge to treat due to the complex interplay between disease‐induced and treatment‐related cytopenias.
Neha Thakre, Corinna Maier, Jiuhong Zha, Benjamin Engelhardt, Johannes E. Wolff, Sven Mensing   +5 more
wiley   +1 more source

Bayesian Clinical Trial Design for Distributional Outcomes with Noncompliance. [PDF]

Entropy (Basel)
Guo X, Yang Z, Li S, Shen W.
europepmc   +1 more source