Results 101 to 110 of about 140,199 (296)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

8. Mistake

Without assuming prior legal knowledge, books in the Directions series introduce and guide readers through key points of law and legal debate. Questions, figures and exercises help readers to engage fully with each subject and check their understanding ...
Damian Taylor, Richard Taylor
core   +1 more source

Đlköğretim Đkinci Kademe Matematik Öğretmenlerinin Yanlışlara Dönüt Vermede Kullandıkları Dönüt Teknikleri

Ankara Üniversitesi Eğitim Bilimleri Fakültesi Dergisi, 2012
Davranışçı kuramlarda yanlış görmezden gelinmiştir. Bilişsel kuramlarda sadece kavram yanılgısı olan yanlışlara önem verilmiştir. Yapılandırmacı yaklaşımda ise yanlış öğrenme için önemli bir fırsat ve öğrenme ortamının kaçınılmaz bir parçasıdır. Fakat
Ali TÜRKDOĞAN, Adnan BAKİ
doaj  

Eine Bibliografie des Scheiterns im Bibliothekswesen

Bibliothek
Die Fragen, wie und warum Projekte im bibliothekarischen Umfeld scheitern und wie mit solchen Misserfolgen produktiv umgegangen werden kann, werden in Fachpublikationen immer wieder gestellt.
Kilian Andrej, Renn Oliver
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Common Mistake in Contract Law

, 2009
English law has long struggled to understand the effect of a fundamental common mistake in contract formation. Bell v Lever Brothers Ltd [1932] AC 161 recognises that a common mistake which totally undermines a contract renders it void.
Capper, David; id_orcid
core   +2 more sources

International trade law and common mistake: has there really been a satisfactory clarification of what fundamental legal principles apply?

, 2006
Common Mistake is an important fundamental legal principle. This article examines the recent legal developments arising out of caselaw and considers the impact of same on the clarity of the statements of the fundamental ...
Taylor, Des
core   +1 more source

A Critique of ‘Arafat al-‘Asheghin Publication: An Evidence for Requirements of Correcting Persian Literary Tazkerehs [PDF]

متن شناسی ادب فارسی, 2015
‘Arafat al-‘Ashegin va ‘Arasat al-‘Arefin is one of the most important ancient Persian literary Tazkerehs and is considered as the most complete work in its genre.
سعید شفعیون
doaj