FEBS Open Bio, EarlyView.The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley +1 more source
Correction: Liu, X.; Lin, Y. YOLO-GW: Quickly and Accurately Detecting Pedestrians in a Foggy Traffic Environment. <i>Sensors</i> 2023, <i>23</i>, 5539. [PDF]
Sensors (Basel)Liu X, Lin Y.
europepmc +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Corrigendum: Is the diaphragm thickness related to gait speed in patients with hemiplegia caused by cerebrovascular accident? [PDF]
J Phys Ther Scieuropepmc +1 more source
Improving Diagnosis: Evaluation of Diagnostic Experiences Classified as Problems, Mistakes, or Both by Patients and Care Partners From a Nationally Representative Survey. [PDF]
Med CareGleason KT +6 more
europepmc +1 more source
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Correction: Regulatory actions of LH and follicle-stimulating hormone on breast cancer cells and mammary tumors in rats. [PDF]
Front Endocrinol (Lausanne)Sanchez AM +8 more
europepmc +1 more source