Results 131 to 140 of about 2,542,003 (361)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Building A High-Resolution Vegetation Outlook Model to Monitor Agricultural Drought for the Upper Blue Nile Basin, Ethiopia

Remote Sensing, 2019
To reduce the impacts of drought, developing an integrated drought monitoring tool and early warning system is crucial and more effective than the crisis management approach that is commonly used in developing countries like Ethiopia.
Yared Bayissa, Tsegaye Tadesse, Getachew Demisse   +2 more
doaj   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Benefit-Cost Analysis of FEMA Hazard Mitigation Grants [PDF]

Mitigation ameliorates the impact of natural hazards on communities by reducing loss of life and injury, property and environmental damage, and social and economic disruption.
Adam Rose, Anne S. Kiremidjian, Carol Taylor West, Charles Huyck, Craig Taylor, David Godschalk, Douglass Shaw, Jawhar Bouabid, John C. Whitehead, Kathleen, Keith Porter, L. Thomas Tobin, Nicole Dash, Philip T. Ganderton, Ronald T. Eguchi, Thomas R. McLane   +15 more
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Characteristic Analysis and Forecast of Sea Fog Weather in Rizhao City

Haiyang Kaifa yu guanli, 2023
Large quantity of observational data from ground and sounding meteorological observation data, ocean station observation data, ERA reanalysis data are used to count the sea fog process that occurred during April to July in Rizhao City from 1988 to 2019 ...
Zhiyong ZHENG, Sen DING, Zhenzhen WANG, Yingying LIU, Lida FENG, Jiling HOU, Shuai HUANG, Congcong ZHENG   +7 more
doaj  

Adaptation, Mitigation and Innovation: A Comprehensive Approach to Climate Policy [PDF]

The ultimate question that most interests policy makers is how to reduce the climate change vulnerability of socio-economic systems in the most cost-effective manner. Extended literature has investigated the different dimensions of mitigation strategies,
Carlo Carraro, Enrica De Cian, Francesco Bosello, Shardul Agrawala   +3 more
core  

Mitigation and adaptation strategies – organic agriculture [PDF]

, 2009
Andreas Fließbach, P Maeder, Amadou Makhtar Diop, Louise Luttikholt, Nadia El‐Hage Scialabba, U. Niggli, Paul Heyyerly, T LaSalle   +7 more
openalex   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Mitigation of Malicious Attacks on Networks

, 2011
Terrorist attacks on transportation networks have traumatized modern societies. With a single blast, it has become possible to paralyze airline traffic, electric power supply, ground transportation or Internet communication. How and at which cost can one
Andrade Jr., Jose S., Havlin, Shlomo, Herrmann, Hans J., Moreira, Andre A., Schneider, Christian M.   +4 more
core   +2 more sources