Results 361 to 370 of about 1,007,169 (424)

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Targeted Delivery of α‐ketoglutarate to Macrophages in Bone: A Novel Therapeutic Strategy for Improving Fracture Healing in Type 2 Diabetes

Advanced Science, EarlyView.
The study reveals that glutaminolysis in macrophages is inhibited under type 2 diabetes mellitus (T2DM) conditions, which impedes fracture healing by reducing bone morphogenetic protein 2 (BMP2) production through increased cytosine methylation on the promoter.
Jing Wang, Jiahao Cao, Siqi Zhang, Hongli Chen, Xuebing Yu, Xinli Wang, Tianji Wang, Wei Cao, Wengang Dong, Xinsen Lin, Jia Li, Wei Lei, Yafei Feng   +12 more
wiley   +1 more source

Mitochondria-associated non-coding RNAs and their impact on drug resistance. [PDF]

Front Pharmacol
An X, Sun L, Zheng H, Xiao Y, Sun W, Yu D.   +5 more
europepmc   +1 more source

Unlocking the Promise of Antitumor Hyperthermia‐Immunotherapy with Spiky Surface Topology

Advanced Science, EarlyView.
MNP@Spiky nanoparticles are designed for efficient uveal melanoma treatment. After intraocular injection, tumor cells are disrupted directly by magnetic hyperthermia effect caused by the Fe3O4 core and released tumor‐associated antigens to initiate anti‐tumor immune responses.
Muyue Yang, Yan Yu, Tongxin Ge, Qiuyi Zhu, Ai Zhuang, Wenxing Wang, Xianqun Fan   +6 more
wiley   +1 more source

Mitochondria-Targeted Temozolomide Probe for Overcoming MGMT-Mediated Resistance in Glioblastoma. [PDF]

Chembiochem
Szames D, Kelley SO.
europepmc   +1 more source

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Advanced Science, EarlyView.
This work develops a cyanine dye named Cy‐BF and encapsulates it with phospholipids and platelet exosome vesicles to create CHL. Characterized by high phototoxicity, low dark toxicity, and enhanced tumor targeting, CHL demonstrates aggregation‐induced broadening of absorption spectra and NIR‐activated photothermal therapy and type I photodynamic ...
Yongjian Zhang, Xiaohong Wu, Kaiyuan Wang, Yaohan Tang, Xiuxin Lu, Fusheng Sun, Hua Tang, Xiaoyuan Chen, Shipeng Ning   +8 more
wiley   +1 more source

Mitochondrial Localization and Function of Adenosine Receptors. [PDF]

Int J Biol Sci
Sánchez-Melgar A, Vultaggio-Poma V, Falzoni S, Fructuoso C, Albasanz JL, Di Virgilio F, Martín M.   +6 more
europepmc   +1 more source

The Association Among Bipolar Disorder, Mitochondrial Dysfunction, and Reactive Oxygen Species. [PDF]

Biomolecules
Kageyama Y, Okura S, Sukigara A, Matsunaga A, Maekubo K, Oue T, Ishihara K, Deguchi Y, Inoue K.   +8 more
europepmc   +1 more source

The impact of mitochondrial dysfunction on ovarian aging. [PDF]

J Transl Med
Zhang X, Zhang L, Xiang W.
europepmc   +1 more source

Generation of a Transgenic Mouse Model for Investigating Mitochondria in Sperm. [PDF]

Cells
Sarkar H, Batta SR, Wadhwa N, Majumdar SS, Pradhan BS.   +4 more
europepmc   +1 more source