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The Mitochondrial Genome And Human Mitochondrial Diseases
Journal of the Peripheral Nervous System, 2002To date, more than 100 point mutations and several hundreds of structural rearrangements of mitochondrial DNA (mtDNA) are known too be connected with characteristic neuromuscular and other mitochondrial syndromes varying from those causing death at the neonatal stage to diseases with late ages of onset. The immediate cause of mitochondrial disorders is
R I, Sukernik +8 more
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The mitochondrial genome and mitochondrial muscle disorders
Current Opinion in Pharmacology, 2001Mitochondrial disorders represent a multitude of clinically heterogeneous diseases in which the genetic abnormality can involve either a mitochondrial or nuclear gene. In addition to inherited defects, somatic mitochondrial DNA mutations have been implicated in the pathogenesis of neurodegenerative disease, cancer and the ageing process.
A M, Schaefer +2 more
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Mitochondrial genomics flies high
Trends in Ecology & Evolution, 2001A new pair of papers reports the complete coding sequences for 28 mitochondrial DNAs in Drosophila. By examining the patterns of polymorphism and divergence among functionally distinct classes of synonymous and nonsynonymous nucleotide sites, Bill Ballard provides a comprehensive whole-genome picture of how mtDNA sequence evolution can depart from the ...
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2021
The mitochondrial genome is the second genome for eukaryotes. It has essential functions in many cellular processes, including producing energy, signaling, aging, and programmed cell death. Up to now, ten mitochondrial genomes from seven Ganoderma species had been released on the public database. The mitochondrial genomes of each species were described
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The mitochondrial genome is the second genome for eukaryotes. It has essential functions in many cellular processes, including producing energy, signaling, aging, and programmed cell death. Up to now, ten mitochondrial genomes from seven Ganoderma species had been released on the public database. The mitochondrial genomes of each species were described
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The Aspergillus nidulans mitochondrial genome
Current Genetics, 1985A brief description is provided of the overall organisation of the Aspergillus nidulans mitochondrial genome, as revealed by DNA sequence analysis.
T A, Brown +3 more
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Genomic Strategies in Mitochondrial Diagnostics
2023Pathogenic variants in both mitochondrial and nuclear genes contribute to the clinical and genetic heterogeneity of mitochondrial diseases. There are now pathogenic variants in over 300 nuclear genes linked to human mitochondrial diseases. Nonetheless, diagnosing mitochondrial disease with a genetic outcome remains challenging.
Deen D +4 more
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Angiosperm mitochondrial genomes and mutations
Mitochondrion, 2008Flowering plants harbor the largest mitochondrial genomes reported so far. At present, the nucleotide sequences of 15 mitochondrial genomes from seven angiosperm species are available, making detailed comparative analysis feasible. The gene content is variable among the species, but the most striking feature is the fluidity of intergenic regions, where
Tomohiko, Kubo, Kathleen J, Newton
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The mitochondrial genome of yeast
Cell, 1978mtDNA is the simplest DNA in nature which carries genes for the three classes of RNA-rRNAs, tRNAs, and mRNAs. In yeast, this genetic system has a number of unusual features that may even be of interest to molecular biologists who do not particularly care about mitochondrial biogenesis: -The gene for the large rRNA is split and the intervening sequence ...
P, Borst, L A, Grivell
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2007
Plant mitochondria share a functional role with their fungal and animal counterparts, and their genomes have a number of genes in common. In almost every other aspect, however, plant mitochondrial genomes differ. Whereas animal genomes are very small (14-18 kb) and fungal genomes somewhat larger (70-100 kb), known plant mitochondrial genomes range in ...
C. Fauron +3 more
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Plant mitochondria share a functional role with their fungal and animal counterparts, and their genomes have a number of genes in common. In almost every other aspect, however, plant mitochondrial genomes differ. Whereas animal genomes are very small (14-18 kb) and fungal genomes somewhat larger (70-100 kb), known plant mitochondrial genomes range in ...
C. Fauron +3 more
openaire +1 more source