Results 141 to 150 of about 902,534 (304)

Mitochondrial Ribosomal Proteins and Cancer

Medicina
Mitochondria play key roles in maintaining cell life and cell function, and their dysfunction can lead to cell damage. Mitochondrial ribosomal proteins (MRPs) are encoded by nuclear genes and are assembled within the mitochondria.
Huiyi Wu, Xiaowei Zhu, Huilin Zhou, Min Sha, Jun Ye, Hong Yu   +5 more
doaj   +1 more source

Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. [PDF]

Mol Psychiatry, 2023
Campbell PD, Lee I, Thyme S, Granato M.
europepmc   +1 more source

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

The mitochondrial proteome of diplonemids: from conventional pathways to eccentric RNA editing and transcript processing

BMC Genomics
Background Diplonemids constitute an abundant and geographically widespread but little-studied group of marine protists. A hallmark of this lineage, the kinetoplastid sister group within Euglenozoa, is a mitochondrial genome comprising numerous small ...
Michael W. Gray, Matus Valach, Matt Sarrasin, Felix-Antoine Le Sieur, Julius Lukeš, Gertraud Burger   +5 more
doaj   +1 more source

Roles of O-GlcNAcylation in Mitochondrial Homeostasis and Cardiovascular Diseases

Antioxidants
Protein posttranslational modifications are important factors that mediate the fine regulation of signaling molecules. O-linked β-N-acetylglucosamine-modification (O-GlcNAcylation) is a monosaccharide modification on N-acetylglucosamine linked to the ...
Zhen Qiu, Jiahui Cui, Qin Huang, Biao Qi, Zhongyuan Xia   +4 more
doaj   +1 more source

Systematic Approaches to Study Eclipsed Targeting of Proteins Uncover a New Family of Mitochondrial Proteins. [PDF]

Cells, 2023
Mark M, Klein O, Zhang Y, Das K, Elbaz A, Hazan RN, Lichtenstein M, Lehming N, Schuldiner M, Pines O.   +9 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Endogenous TOM20 Proximity Labeling: A Swiss-Knife for the Study of Mitochondrial Proteins in Human Cells. [PDF]

Int J Mol Sci, 2023
Meurant S, Mauclet L, Dieu M, Arnould T, Eyckerman S, Renard P.   +5 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Protocol for mitochondrial isolation and sub-cellular localization assay for mitochondrial proteins. [PDF]

STAR Protoc, 2023
Zhou D, Zhong S, Han X, Liu D, Fang H, Wang Y.   +5 more
europepmc   +1 more source