Results 261 to 270 of about 520,457 (360)

Targeting the hypoxia‐inducible factor‐1 alpha‐exoVEGF axis in tumor‐associated macrophages overcomes Bacillus Calmette‐Guérin immunotherapy resistance

Interdisciplinary Medicine, EarlyView.
Macrophages stimulated by BCG significantly enhanced endothelial cell proliferation, migration, and tube formation. Mechanistically, this pro‐angiogenic activity was reliant on activating NF‐αB or other signaling pathways, which induced the upregulation of HIF‐1α and VEGFA.
Yuyang Hou, Yuxi Wang, Qiong Wu, Wenjing Du, Shanzhu Guo, Xinyu Chai, Yinan Wang, Huixin Liang, Hongyan Yuan, Jun Li, Dongmei Yan   +10 more
wiley   +1 more source

Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation. [PDF]

Research (Wash D C)
Zhu M, Zhu W, Pan J, Chen Z, Yan Y, Wang S, Zhang T, Yang X, Xu H, Kong X, Hu H, Xu S, Zhang X, Zhang B, Liao C, Duan Y, Yang S, Chen Y.   +17 more
europepmc   +1 more source

Mimicking DOUGONG brackets orchestrate regulating inflammation and mechanical stimuli for osteochondral regeneration using 3D printing

Interdisciplinary Medicine, EarlyView.
Akermanite scaffolds promote osteogenic differentiation of BMSCs through regulating the PI3K/Akt signaling pathway, and strontium ions enhance the akermanite effects by mediating the cytokine‐cytokine receptor interaction pathway. Thus, the enhancements of osteogenesis in subchondral bone coupled with the chondral‐promoting effects of chondrocytes ...
Bo Li, Yaqi Zhang, Xuerui Zhou, Weiguo Wang, Fan Yang, Qiushi Wei, Leilei Chen, Ziqi Li, Mincong He, Xiaoming He, Shengting Chai, Xiuhong Cao, Rui Wang, Tongmeng Jiang, Chen Wang, Wei He   +15 more
wiley   +1 more source

Long-term Ocular Safety in Children Treated with Mitogen-Activated Protein Kinase Pathway Inhibitor Therapy. [PDF]

Ophthalmology
Avery RA, Gross AM, Cousineau-Krieger C, Keenan TDL, McManus T, Dallas CJ, Hampton C, Baldwin A, Jin F, Heisey K, Zeller K, Liu GT, Okeagu C, Bishop RJ, Fisher MJ, Widemann BC, Magone MT.   +16 more
europepmc   +1 more source

Impact of organic pollutants on phenotype and gene expression in human breast cancer cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Human exposure to industrial chemical compounds is widespread and, although often beneficial, prolonged contact may contribute to disease development, including cancer. While many studies have shown organic pollutants (OP) are cytotoxic, few have explored how long‐term exposure alters cell phenotype.
Camila Confortin, Heloisa Amancio, Jessica Zablocki da Luz, Aliciane de Almeida Roque, Tugstênio Lima de Souza, José Eduardo Vargas, Ciro Alberto de Oliveira Ribeiro, Francisco Filipak Neto   +7 more
wiley   +1 more source

Mitogen-Activated Protein Kinase Phosphatase-5 is Required for TGF-β Signaling Through a JNK-Dependent Pathway. [PDF]

Mol Cell Biol
Dorry S, Perla S, Bennett AM.
europepmc   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Isolated gastrointestinal Langerhans cell histiocytosis in a 16‐month‐old child: A case report

JPGN Reports, EarlyView.
Abstract Langerhans cell histiocytosis (LCH) is a rare disorder characterized by clonal proliferation of Langerhans cells, most often involving the skin or bone. Isolated gastrointestinal (GI) involvement is extremely uncommon in young children. We report a 16‐month‐old girl with a 1‐month history of chronic vomiting, bloody diarrhea, and failure to ...
Al‐Qasim AL‐Bahlani, Laraib Touseeq, Mohammed Al‐Masqari, Emad Saad   +3 more
wiley   +1 more source

A glucocorticoid-regulating molecule, Fkbp5, may interact with mitogen-activated protein kinase signaling in the organ of Corti of mice cochleae. [PDF]

Sci Rep
Sato A, Omichi R, Maeda Y, Ando M.
europepmc   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source