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Mitogen-activated protein kinase pathways
Current Opinion in Cell Biology, 1997Nearly all cell surface receptors utilize one or more of the mitogen-activated protein kinase cascades in their repertoire of signal transduction mechanisms. Recent advances in the study of such cascades include the cloning of genes encoding novel members of the cascades, further definition of the roles of the cascades in responses to extracellular ...
M J, Robinson, M H, Cobb
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Mitogen-activated protein kinases
Critical Care Medicine, 2002The cellular control switches are regulated through an extensive network of interactive intracellular signal transduction pathways, such as the mitogen-activated protein kinase (MAPK) family. The MAPK pathways may play an important role in the inappropriate inflammatory responses that lead to systemic inflammatory response syndrome or multiple organ ...
Saman, Arbabi, Ronald V, Maier
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Mitogenâactivated protein kinases and asthma
Journal of Cellular Physiology, 2004AbstractMitogenâactivated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical ...
PELAIA G. +10 more
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Novel mitogen-activated protein kinase kinase inhibitors
Expert Opinion on Investigational Drugs, 2011the development of new drugs over the last few decades has targeted specific proteins thought to be a key to the disease state. MAPK kinases 1 and 2 (commonly known as MEK1-2) represent such proteins as they lie downstream of important drug targets for oncology, such as EGFR, RAS and RAF.
Mark S, Chapman, Jeffrey N, Miner
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Mitogen-Activated Protein Kinase Signaling
2004The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and ...
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Mitogen-Activated Protein Kinase Kinase 4 (MKK4)
The International Journal of Biochemistry & Cell Biology, 2000The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines. JNK is a member of the MAP kinase family and a key component of a stress activated protein kinase signalling pathway ...
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Mitogen-Activated Protein Kinase Assays
2007Polymorphonuclear neutrophils (PMN) play an essential role in host defense against bacteria and fungi through coordinated responses such as adhesion, migration, phagocytosis, secretion, and activation of the NADPH oxidase. The mitogen-activated protein kinases (MAPKs) and their activation kinase cascades, which transduce signals from the plasma ...
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Mitogen-activated protein kinases in schizophrenia
Biological Psychiatry, 1999Mitogen-activated protein kinases (MAPKs) are important mediators of signal transduction from the cell surface to the nucleus and have been implicated in the integration of a variety of physiologic processes in most cells, including neurons. To investigate the possible involvement of MAPKs in schizophrenia, we compared the levels of the MAPK ...
S V, Kyosseva +5 more
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The mitogen-activated protein kinase activator
Current Opinion in Cell Biology, 1992The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and in identifying another protein ...
N G, Ahn, R, Seger, E G, Krebs
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