Results 41 to 50 of about 4,675,421 (262)
MAPK signaling regulates the efficacy of chemoimmunotherapy
Molecular & Cellular Oncology, 2022 Resistance to chemoimmunotherapy is a major issue for cancer care. We recently unravelled the role of mitogen-activated protein kinase (MAPK) to limit the antitumor efficacy of such combination.
François Ghiringhelli
doaj +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Cells, 2020 : Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj +1 more source
Frontiers in Physiology, 2021 Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li +8 more
doaj +1 more source
MAP2K4 (mitogen-activated protein kinase kinase 4) [PDF]
, 2012 Review on MAP2K4 (mitogen-activated protein kinase kinase 4), with data on DNA, on the protein encoded, and where the gene is ...
Nakayama, K, Nakayama, N, Miyazaki, K
core +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. [PDF]
PLoS ONE, 2014 Prostate cancer (PCa) is the second leading cause of cancer death in the US. Death from PCa primarily results from metastasis. Mitogen-activated protein kinase kinase 4 (MAP2K4) is overexpressed in invasive PCa lesions in humans, and can be inhibited by ...
Janet M Pavese +6 more
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The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
BMC Cardiovascular Disorders, 2021 Background Exposure to glyoxal, the smallest dialdehyde, is associated with several diseases; humans are routinely exposed to glyoxal because of its ubiquitous presence in foods and the environment.
Ming-Zhang Xie +9 more
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Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationSummary
Cellular and Molecular Gastroenterology and Hepatology, 2023 Background and Aims: The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. An imbalance in this highly regimented process within the intestinal crypts is associated with several intestinal pathologies ...
Chang Li +11 more
doaj +1 more source