Results 41 to 50 of about 402,887 (303)

Selenoproteins Protect Against Avian Liver Necrosis by Metabolizing Peroxides and Regulating Receptor Interacting Serine Threonine Kinase 1/Receptor Interacting Serine Threonine Kinase 3/Mixed Lineage Kinase Domain-Like and Mitogen-Activated Protein Kinase Signaling

Frontiers in Physiology, 2021
Liver necroptosis of chicks is induced by selenium (Se)/vitamin E (VE) deficiencies and may be associated with oxidative cell damage. To reveal the underlying mechanisms of liver necrosis, a pool of the corn–soy basal diet (10 μg Se/kg; no VE added), a ...
Tong Li, Jing Zhang, Jing Zhang, Peng-Jie Wang, Peng-Jie Wang, Zi-Wei Zhang, Zi-Wei Zhang, Jia-Qiang Huang, Jia-Qiang Huang   +8 more
doaj   +1 more source

Integration of a Phosphatase Cascade with the MAP Kinase Pathway provides for a Novel Signal Processing Function [PDF]

, 2009
We mathematically modeled the receptor-activated MAP kinase signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAP kinase pathway.
Alon, Altan-Bonnet, Bettini, Bhalla, Birtwistle, Blüthgen, Bollen, Brondello, Camps, Castelli, Chang, Cobb, Cyert, Das, Dickinson, Dickinson, Ebisuya, Echevarria, Eungdamrong, Ferrell, Friedman, Hatakeyama, Heinrich, Huang, Karlsson, Keyse, Kholodenko, Kolch, Kolch, Kumar, Kumar, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Kurosaki, Levchenko, Locasale, Manders, Muda, Orton, Qiao, Raman, Reth, Rolli, Santos, Schmidt, Singh, Tan, Tian, Ueki, Widmann, Zandomeni, Zhao, Zi   +54 more
core   +3 more sources

Myocardial depressant effects of interleukin 6 in meningococcal sepsis are regulated by p38 mitogen-activated protein kinase [PDF]

, 2011
Our findings demonstrate an integral role of the p38 mitogen-activated protein kinase pathway in interleukin 6-mediated cardiac contractile dysfunction and inotrope insensitivity.
Abraham, Alizadeh, Angus, Asaduzzaman, Bellahcene, Benjamini, Bernard, Boucek, Branger, Chang, Checchia, Chen, Chen, Cheryl A. Hemingway, Chopra, Crackower, Cuenda, Cvijanovich, David A. Relman, Dhingra, Dong, Fourrier, Gentleman, Haralambous, Hariklia Eleftherohorinou, Hilger, Hotchkiss, Hubble, Jayne L. Dennis, Joanne L. Franklin, Kaminska, Kanehisa, Kishimoto, Kumar, Leblais, Levin, Liu, Liu, Ma, Martin, Mi, Michael Griffiths, Michael Levin, Mockridge, Narazaki, Nazima Pathan, Opal, Osuchowski, Padkin, Parasrampuria, Pathan, Pathan, Popper, Riedemann, Schumann, Shanley, Sian E. Harding, Simon J. Waddell, Smyth, Song, Su, Talmor, Victoria J. Wright, Waage, Wang, Watson, Yang, Yu, Zarubin   +68 more
core   +1 more source

Sirolimus for Extracranial Arteriovenous Malformations: A Scoping Review of the Evidence in Syndromic and Non‐Syndromic Cases

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Arteriovenous malformations (AVMs) are rare, high‐flow, vascular anomalies that can occur either sporadically or as part of a genetic syndrome. AVMs can progress with serious morbidity and even mortality if left unchecked. Sirolimus is an mTOR inhibitor that is effective in low‐flow vascular malformations; however, its role in AVMs is unclear.
Will Swansson, Ingrid Winship, Gary Hammerschlag, Laura Scardamaglia   +3 more
wiley   +1 more source

Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]

, 2015
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, David Kipling, Irina Chuckowree, Jessica Dwyer, Kyriakis, Lee, Mark Bagley, Meyn, Mohammed Baashen, Terence Davis, Thannhauser   +10 more
core   +7 more sources

ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis

Cells, 2020
: Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates downstream JNK and p38 mitogen-activated protein kinase (MAPK) to relay death signals into cells in response to various ...
Jianxin Huo, Shengli Xu, Kong-Peng Lam
doaj   +1 more source

Mitogen-activated protein kinase kinase 4 (MAP2K4) promotes human prostate cancer metastasis. [PDF]

PLoS ONE, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in the US. Death from PCa primarily results from metastasis. Mitogen-activated protein kinase kinase 4 (MAP2K4) is overexpressed in invasive PCa lesions in humans, and can be inhibited by ...
Janet M Pavese, Irene M Ogden, Eric A Voll, Xiaoke Huang, Li Xu, Borko Jovanovic, Raymond C Bergan   +6 more
doaj   +1 more source

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]

, 2016
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S., de Jesus Perez, Vinicio, MacLean, Margaret, West, James D.   +3 more
core   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Glycolytic Regulation of Intestinal Stem Cell Self-Renewal and DifferentiationSummary

Cellular and Molecular Gastroenterology and Hepatology, 2023
Background and Aims: The intestinal mucosa undergoes a continual process of proliferation, differentiation, and apoptosis. An imbalance in this highly regimented process within the intestinal crypts is associated with several intestinal pathologies ...
Chang Li, Yuning Zhou, Ruozheng Wei, Dana L. Napier, Tomoko Sengoku, Michael C. Alstott, Jinpeng Liu, Chi Wang, Yekaterina Y. Zaytseva, Heidi L. Weiss, Qingding Wang, B. Mark Evers   +11 more
doaj   +1 more source