Results 71 to 80 of about 4,675,421 (262)

Oxycodone self-administration activates the mitogen-activated protein kinase/ mitogen- and stress-activated protein kinase (MAPK-MSK) signaling pathway in the rat dorsal striatum

Scientific Reports, 2021
To identify signaling pathways activated by oxycodone self-administration (SA), Sprague–Dawley rats self-administered oxycodone for 20 days using short—(ShA, 3 h) and long-access (LgA, 9 h) paradigms.
Christopher A. Blackwood, Michael T. McCoy, Bruce Ladenheim, Jean Lud Cadet   +3 more
doaj   +1 more source

MAPK8 (mitogen-activated protein kinase 8) [PDF]

, 2003
Review on MAPK8 (mitogen-activated protein kinase 8), with data on DNA, on the protein encoded, and where the gene is ...
Chen, F
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

MAPK4 (mitogen-activated protein kinase 4) [PDF]

, 2009
Review on MAPK4 (mitogen-activated protein kinase 4), with data on DNA, on the protein encoded, and where the gene is ...
Meloche, S
core   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Research Progress of Dual-Specificity Phosphatase in Diabetic Nephropathy

Xiehe Yixue Zazhi
Diabetic nephropathy(DN), a prevalent microvascular complication of diabetes, has emerged as a leading cause of end-stage renal disease worldwide. Recent studies on the dual-specific phosphatase (DUSP) family have revealed a significant reduction in DUSP
WANG Xiaonian, AO Qi, HUANG Hai, LIE Caihua   +3 more
doaj   +1 more source

MAPK14 (mitogen-activated protein kinase 14) [PDF]

, 2011
Review on MAPK14 (mitogen-activated protein kinase 14), with data on DNA, on the protein encoded, and where the gene is ...
Porras, A, Guerrero Arroyo, María del Carmen, Porras, Almudena, Guerrero, C   +3 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Crosstalks between Raf-kinase inhibitor protein and cancer stem cell transcription factors (Oct4, KLF4, Sox2, Nanog)

Tumor Biology, 2017
Raf-kinase inhibitor protein has been reported to inhibit both the Raf/mitogen extracellular signal–regulated kinase/extracellular signal–regulated kinase and nuclear factor kappa-light-chain of activated B cells pathways.
SoHyun Lee, Stephanie Wottrich, Benjamin Bonavida   +2 more
doaj   +1 more source

MAPK12 (mitogen-activated protein kinase 12) [PDF]

, 2010
Review on MAPK12 (mitogen-activated protein kinase 12), with data on DNA, on the protein encoded, and where the gene is ...
MI Cerezo-Guisado, Cerezo-Guisado, MI, Cuenda, A, A Cuenda   +3 more
core   +1 more source