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Mitogen-Activated Protein Kinases in Endothelial Pathophysiology
Journal Of Investigative Medicine, 2003Endothelial cells continuously respond to extracellular stimuli such as chemical signals produced by circulating blood elements or mechanical forces such as shear stress. Proinflammatory cytokines, mitogens, reactive oxygen species, and shear stress trigger signal molecules to initiate multiple intracellular pathways, which often converge at mitogen ...
Alexander D. Verin +3 more
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Regulation of a Mitogen-Activated Protein Kinase Kinase Kinase, MLTK by PKN
Journal of Biochemistry, 2003PKNalpha is a fatty acid- and Rho-activated serine/threonine protein kinase having a catalytic domain homologous to members of the protein kinase C family. Recently it was reported that PKNalpha is involved in the p38 mitogen-activated protein kinase (MAPK) signaling pathway.
Takayuki Isagawa +7 more
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Mitogen-Activated Protein Kinase Signaling in Plants
Annual Review of Plant Biology, 2010Eukaryotic mitogen-activated protein kinase (MAPK) cascades have evolved to transduce environmental and developmental signals into adaptive and programmed responses. MAPK cascades relay and amplify signals via three types of reversibly phosphorylated kinases leading to the phosphorylation of substrate proteins, whose altered activities mediate a wide ...
Rodriguez, Maria Cristina Suarez +2 more
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Mitogen-Activated Protein Kinase Kinase 4 (MKK4)
The International Journal of Biochemistry & Cell Biology, 2000The Mitogen-Activated Protein Kinase Kinase 4 (MKK4), a member of the MAP kinase kinase family, directly phosphorylates and activates the c-Jun NH2-terminal kinases (JNK), in response to cellular stresses and proinflammatory cytokines. JNK is a member of the MAP kinase family and a key component of a stress activated protein kinase signalling pathway ...
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A continuous spectrophotometric assay for mitogen-activated protein kinase kinases
Analytical Biochemistry, 2012We describe a convenient and simple continuous spectrophotometric method for the determination of mitogen-activated protein kinase (MAPK) kinase activity with its protein substrate. The assay relies on the measurement of phosphoprotein product generated in the first step of the MAPK kinase reaction. Dephosphorylation of the phosphoprotein is coupled to
Zhong Yin Zhang +6 more
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Mitogen-Activated Protein Kinase Signaling
2004The mechanism by which cells respond to extracellular stimuli involves a series of signal transduction events across the cell membrane and through the cytoplasm to the nucleus. Mitogen-activated protein (MAP) kinases are important mediators of signal transduction and play a key role in the regulation of many cellular processes, such as cell growth and ...
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Protein kinase C and mitogen‐activated protein kinase signalling in oligodendrocytes
Microscopy Research and Technique, 2001AbstractOligodendrocytes (OL) play a significant physiological role in the central nervous system by creating the myelin sheath that allows for the efficient conduction of nerve impulses. Therefore, it is important to understand which signalling cascades define the proliferation, differentiation, survival, and myelin formation potential of these cells.
Seung U. Kim, Rochelle L. Stariha
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Mitogen-Activated Protein Kinases and Wound Stress [PDF]
, 2000 One of the most severe environmental stresses that plants encounter during their life cycle is wounding. Plants respond to wound stress by activating a set of genes that encode proteins involved in healing injured tissues. In recent years, mitogen-activated protein kinases have been implicated to be key signal molecules in the initial signal ...
Yuko Ohashi, Shigemi Seo
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Activation of Mitogen‐Activated Protein Kinases in Oligodendrocytes
Journal of Neurochemistry, 1996Abstract: The proliferation and differentiation of oligodendrocyte progenitors are stringently controlled by an interacting network of growth and differentiation factors. Not much is known, however, about the intracellular signaling pathways activated in oligodendrocytes. In this study, we have examined the activation of mitogen‐activated protein (MAP)
Narayan R. Bhat, Peisheng Zhang
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Mitogen-Activated Protein Kinases and Cerebral Ischemia
Molecular Neurobiology, 2001Mitogen-activated protein kinases (MAPKs) have crucial roles in signal transduction from the cell surface to the nucleus and regulate cell death and survival. Recent papers support the hypothesis that neuronal apoptosis and cerebral ischemia induce the robust activation of MAPK cascades.
Nobuo Hashimoto +2 more
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