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Networking with mitogen-activated protein kinases [PDF]

open access: possibleMolecular and Cellular Biochemistry, 1993
Mitogen activated protein (MAP) kinases and their target ribosomal protein S6 (RSK) kinases have been recognized as shared components in the intracellular signaling pathways of many diverse cytokines. Recent studies have extended this protein kinase cascade by identifying the major activator of vertebrate MAP kinases as a serine/threonine/tyrosine ...
Donna Campbell   +8 more
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Mitogen-activated protein kinases

Critical Care Medicine, 2002
The cellular control switches are regulated through an extensive network of interactive intracellular signal transduction pathways, such as the mitogen-activated protein kinase (MAPK) family. The MAPK pathways may play an important role in the inappropriate inflammatory responses that lead to systemic inflammatory response syndrome or multiple organ ...
Saman Arbabi, Ronald V. Maier
openaire   +4 more sources

Mitogen‐activated protein kinases and asthma

Journal of Cellular Physiology, 2004
AbstractMitogen‐activated protein kinases (MAPKs) are evolutionary conserved enzymes which play a key role in signal transduction mediated by cytokines, growth factors, neurotransmitters and various types of environmental stresses. In the airways, these extracellular stimuli elicit complex inflammatory and structural changes leading to the typical ...
PELAIA G.   +10 more
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Mitogen-activated protein kinases in schizophrenia

Biological Psychiatry, 1999
Mitogen-activated protein kinases (MAPKs) are important mediators of signal transduction from the cell surface to the nucleus and have been implicated in the integration of a variety of physiologic processes in most cells, including neurons. To investigate the possible involvement of MAPKs in schizophrenia, we compared the levels of the MAPK ...
Svetlana V. Kyosseva   +5 more
openaire   +3 more sources

The mitogen-activated protein kinase activator

Current Opinion in Cell Biology, 1992
The mitogen-activated protein kinase appears to be regulated by another growth factor regulated kinase, the mitogen-activated protein kinase activator. In the past year, much progress has been made in purifying and characterizing the mitogen-activated protein kinase activator, in determining its primary structure, and in identifying another protein ...
Rony Seger   +2 more
openaire   +3 more sources

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