Results 1 to 10 of about 233,154 (204)

Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]

Biomolecules
Probenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones, David E. Martin, Jackelyn Murray, Fred Sancilio, Ralph A. Tripp   +4 more
doaj   +2 more sources

Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link [PDF]

Cells, 2019
In recent years, the incidence of both liver and biliary tract cancer has increased. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the two most common types of hepatic malignancies.
Chaobo Chen, Leonard J. Nelson, Matías A. Ávila, Francisco Javier Cubero   +3 more
doaj   +2 more sources

Editorial: Mitogen Activated Protein Kinases [PDF]

Frontiers in Cell and Developmental Biology, 2017
Ana Cuenda, José M. Lizcano, José Lozano   +2 more
doaj   +3 more sources

Evolutionary history of the vertebrate mitogen activated protein kinases family. [PDF]

PLoS ONE, 2011
BackgroundThe mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular processes and pathways essential to most organisms. Its evolution is conserved throughout the eukaryotic kingdoms.
Meng Li, Jun Liu, Chiyu Zhang
doaj   +1 more source

Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks

Frontiers in Plant Science, 2020
Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan, Lixia Pan, Ive De Smet, Ive De Smet   +3 more
doaj   +1 more source

MAPK immunoreactivity in streptozotocin-induced diabetic rat testis [PDF]

Acta Cirúrgica Brasileira, 2014
PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes.
Yelız Bozdemır Donmez, Gulnur Kizilay, Yeter Topcu-Tarladacalisir   +2 more
doaj   +1 more source

The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling [PDF]

, 2008
The kinases MSK1 and MSK2 are activated 'downstream' of the p38 and Erk1/2 mitogen-activated protein kinases. Here we found that MSK1 and MSK2 were needed to limit the production of proinflammatory cytokines in response to stimulation of primary ...
A Cuenda, A Soloaga, A Sommer, Andrew Wingate, B Echtenacher, B Echtenacher, BG Stiles, C Platzer, CA Gogos, Claire E Monk, Claus Johansen, D Rittirsch, DM Dambach, ER Ottosen, F Hildebrand, FY Liew, GR Wiggin, GY Song, H Chi, J Bain, J Darragh, J Han, J Rouse, J Simon C Arthur, Jin Mo Park, JM Park, Joanne Darragh, Joanne McIlrath, JS Arthur, JS Arthur, Julia M Carr, KV Salojin, Lars Iversen, M Brook, M Hammer, M Saraiva, ML Steinhauser, MS Lee, NC Riedamann, NW Freshney, Olga Ananieva, OM Peck-Palmer, P Chen, PC Cheung, PJ Murray, Q Zhao, R Kuhn, Rachel Toth, SE Moreno, SJ O'Keefe, SM Miggin, SQ Latifi, Susana G Santos, T Kawai, T Lang, T van der Poll, VA Beardmore, VS Carl, WJ Hubbard, X Zhang, Y Kalechman, YJ Kang   +61 more
core   +3 more sources

Cellular reprogramming through mitogen-activated protein kinases

Frontiers in Plant Science, 2015
Mitogen-activated protein kinase (MAPK) cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes.
Justin eLee, Lennart eEschen-Lippold, Ines eLassowskat, Ines eLassowskat, Ines eLassowskat, Christoph eBoettcher, Christoph eBoettcher, Dierk eScheel   +7 more
doaj   +1 more source

Analysis of pain markers and epidural fibrosis caused by repeated spinal surgery in Sprague–Dawley rats

BMC Musculoskeletal Disorders, 2021
Background Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain.
Meiling Quan, Won-Ha Hwang, Jae-Hoon Kim, Young-Yul Kim   +3 more
doaj   +1 more source

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source