Probenecid Inhibits NLRP3 Inflammasome Activity and Mitogen-Activated Protein Kinases (MAPKs) [PDF]
BiomoleculesProbenecid has long been a versatile drug in pharmacological therapies, primarily known for blocking active tubular secretion in the kidney, affecting both endogenous substances like uric acid and exogenous ones like penicillin.
Les P. Jones +4 more
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Mitogen-Activated Protein Kinases (MAPKs) and Cholangiocarcinoma: The Missing Link [PDF]
Cells, 2019 In recent years, the incidence of both liver and biliary tract cancer has increased. Hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA) are the two most common types of hepatic malignancies.
Chaobo Chen +3 more
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Mechanism of the Mitogen-Activated Protein Kinases/Mammalian Target of Rapamycin Pathway in the Process of Cartilage Endplate Stem Cell Degeneration Induced by Tension Load. [PDF]
Global Spine J, 2023 Zhang Y, Liu C, Li Y, Xu H.
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Evolutionary history of the vertebrate mitogen activated protein kinases family. [PDF]
PLoS ONE, 2011 BackgroundThe mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular processes and pathways essential to most organisms. Its evolution is conserved throughout the eukaryotic kingdoms.
Meng Li, Jun Liu, Chiyu Zhang
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Expanding the Mitogen-Activated Protein Kinase (MAPK) Universe: An Update on MAP4Ks
Frontiers in Plant Science, 2020 Phosphorylation-mediated signaling cascades control plant growth and development or the response to stress conditions. One of the best studied signaling cascades is the one regulated by MITOGEN-ACTIVATED PROTEIN KINASEs (MAPKs).
Lixia Pan +3 more
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MAPK immunoreactivity in streptozotocin-induced diabetic rat testis [PDF]
Acta Cirúrgica Brasileira, 2014 PURPOSE: To evaluate the alterations of two mitogen-activated protein kinases (MAPK)s, extracellular signal regulated kinase (ERK) and c-Jun NH2 terminal kinase (JNK), in the testes of male rats with experimental diabetes.
Yelız Bozdemır Donmez +2 more
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F1000Research, 2020 The p38 family is a highly evolutionarily conserved group of mitogen-activated protein kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all stressful stimuli.
Jiahuai Han, Jianfeng Wu, J. Silke
semanticscholar +1 more source
Cellular reprogramming through mitogen-activated protein kinases
Frontiers in Plant Science, 2015 Mitogen-activated protein kinase (MAPK) cascades are conserved eukaryote signaling modules where MAPKs, as the final kinases in the cascade, phosphorylate protein substrates to regulate cellular processes.
Justin eLee +7 more
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BMC Musculoskeletal Disorders, 2021 Background Epidural fibrosis is one of the aetiologies of pain following a spinal revision surgery. It is reported that the specific members of the mitogen – activated protein kinases (MAPK) family might mediate neuropathic pain.
Meiling Quan +3 more
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The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases (*)
Journal of Biological Chemistry, 1995 AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed ofJun and Fos subunits. The composition, the level and the activity of AP1 complexes are regulated in response to extracellular stimuli. An important role
M. Karin
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