Results 111 to 120 of about 423,744 (290)

Erythrocyte mitogen-activated protein kinases mediate hemolytic events under osmotic and oxidative stress and in hemolytic diseases. [PDF]

Cell Signal, 2022
Hazegh K, Fang F, Kelly K, Sinchar D, Wang L, Zuchelkowski BE, Ufelle AC, Esparza O, Davizon-Castillo P, Page GP, Kanias T.   +10 more
europepmc   +1 more source

Immunosuppressive JAG2+ tumor‐associated neutrophils hamper PD‐1 blockade response in ovarian cancer by mediating the differentiation of effector regulatory T cells

Cancer Communications, EarlyView.
Abstract Background Tumor‐associated neutrophils (TANs) play a critical role in modulating immune responses and exhibit significant heterogeneity. Our previous study demonstrated that jagged canonical Notch ligand 2 (JAG2)+ TANs were associated with an immunosuppressive microenvironment in high‐grade serous ovarian cancer (HGSOC), but the underlying ...
Chenyang Wang, Moran Yang, Yujing Zhong, Kankan Cao, Xueling Wang, Chen Zhang, Yiying Wang, Mengdi He, Jiaqi Lu, Guodong Zhang, Yan Huang, Haiou Liu   +11 more
wiley   +1 more source

Compound Mutations in the Abl1 Kinase Cause Inhibitor Resistance by Shifting DFG Flip Mechanisms and Relative State Populations [PDF]

arXiv
The intrinsic dynamics of most proteins are central to their function. Protein tyrosine kinases such as Abl1 undergo significant conformational changes that modulate their activity in response to different stimuli. These conformational changes constitute a conserved mechanism for self-regulation that dramatically impacts kinases' affinities for ...
arxiv  

Regulation of Arabidopsis Matrix Metalloproteinases by Mitogen-Activated Protein Kinases and Their Function in Leaf Senescence. [PDF]

Front Plant Sci, 2022
Wu H, Si Q, Liu J, Yang L, Zhang S, Xu J.   +5 more
europepmc   +1 more source

Functional coupling of SSTR4, a major hippocampal somatostatin receptor, to adenylate cyclase inhibition, arachidonate release and activation of the mitogen-activated protein kinase cascade.

, 1994
Haruhiko Bito, M Mori, Chie Sakanaka, Tomoko Takano, Zen-ichiro Honda, Yukiko Gotoh, Eisuke Nishida, Takao Shimizu   +7 more
openalex   +1 more source

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

Molecule Generation for Target Protein Binding with Hierarchical Consistency Diffusion Model [PDF]

arXiv
Effective generation of molecular structures, or new chemical entities, that bind to target proteins is crucial for lead identification and optimization in drug discovery. Despite advancements in atom- and motif-wise deep learning models for 3D molecular generation, current methods often struggle with validity and reliability.
arxiv  

Functional analysis of mitogen-activated protein kinases (MAPKs) in potato under biotic and abiotic stress. [PDF]

Mol Breed, 2022
Majeed Y, Zhu X, Zhang N, Rasheed A, Tahir MM, Si H.   +5 more
europepmc   +1 more source

Mitogen‐activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

EMBO Journal, 1997
A. Waskiewicz, A. Flynn, C. Proud, Jonathan A. Cooper   +3 more
semanticscholar   +1 more source

Mitogen‐activated protein kinases phosphorylate nuclear lamins and display sequence specificity overlapping that of mitotic protein kinase p34^cdc2 [PDF]

, 1992
Marcus E. Peter, Jasbinder S. Sanghera, Steven Pelech, Erich A. Nigg   +3 more
openalex   +1 more source