Results 251 to 260 of about 423,744 (290)

Shielding Human Adipocytes From Inflammation: The Protective Potential of Polyphenol‐Rich Opuntia ficus‐indica Cladode Extract

Molecular Nutrition &Food Research, EarlyView.
Inflammation of the adipose tissue contributes to metabolic disorders. OFI‐CE regulates the expression of proinflammatory genes in human hypertrophic fat cells. OFI‐CE is a promising candidate for use as a dietary supplement or therapeutic agent in nutritional interventions targeting inflammatory markers associated with obesity.
Stefano Quarta, Nadia Calabriso, Maria Annunziata Carluccio, Clara Albano, Ibrahim Khalifa, Martin Wabitsch, Federica Blando, Marika Massaro   +7 more
wiley   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Beta cells to brain cells: The pivotal role of insulin and glucose metabolism in Alzheimer's disease

Neuroprotection, EarlyView.
Common metabolic, histochemical, and molecular pathologies: Type 2 diabetes and dementia. Abstract The risk factors and neuropathologies of cognitive decline and the onset and progression of dementia‐related disorders were, until recently, obtuse. A critical predisposing factor to Alzheimer's disease (AD) that has emerged is glucose dysmetabolism.
Stanley S. Schwartz, Elizabeth M. Rhea, William A. Banks, Mary E. Herman   +3 more
wiley   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

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Mitogen-activated protein kinases in innate immunity

Nature Reviews Immunology, 2013
J Simon C Arthur, Steven C Ley, Yu Cai
exaly   +2 more sources

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK.

Science, 1994
Growth factors activate mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinases (ERKs) and Jun kinases (JNKs). Although the signaling cascade from growth factor receptors to ERKs is relatively well understood, the ...
A. Minden, A. Lin, M. McMahon, C. Lange-Carter, B. Dérijard, R. Davis, G. Johnson, M. Karin   +7 more
semanticscholar   +1 more source

Cell and Developmental Biology of Plant Mitogen-Activated Protein Kinases.

Annual Review of Plant Biology, 2018
Plant mitogen-activated protein kinases (MAPKs) constitute a network of signaling cascades responsible for transducing extracellular stimuli and decoding them to dedicated cellular and developmental responses that shape the plant body.
G. Komis, O. Šamajová, M. Ovečka, J. Šamaj   +3 more
semanticscholar   +1 more source

Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis.

Arthritis & Rheumatism, 2000
OBJECTIVE To investigate whether stress- and mitogen-activated protein kinases (SAPK/MAPK), such as extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK, are significantly activated in rheumatoid arthritis (RA ...
G. Schett, M. Tohidast-Akrad, J. Smolen, B. J. Schmid, C. Steiner, P. Bitzan, P. Zenz, K. Redlich, Qingbo Xu, G. Steiner   +9 more
semanticscholar   +1 more source