Results 1 to 10 of about 25,236 (117)
Versatile HIV Rev-dependent reporter cell system for stringent and sensitive quantification of viral reservoirs, neutralizing antibodies, and restriction factors [PDF]
RetrovirologyDetecting and measuring HIV reservoirs, neutralizing antibodies, and restriction factors are important for HIV cure research and the development of new therapeutics and vaccines.
Mark Spear +14 more
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Targeting mitochondrial translation and OXPHOS in high-grade serous ovarian carcinoma eliminates stem-like cells [PDF]
Cell Death and DiseaseEx vivo stem cell self-renewal and maintenance is supported by absence of serum-derived mitogens. In the present study, we sought to elucidate the proteomes of stem-like cells grown in serum-free media across a panel of high-grade serous ovarian cancer ...
Aravindan Narayanan +3 more
doaj +2 more sources
Self-Generated Gradients Yield Exceptionally Robust Steering Cues
Frontiers in Cell and Developmental Biology, 2020 Chemotaxis is a widespread mechanism that allows migrating cells to steer to where they are needed. Attractant gradients may be imposed by external sources, or self-generated, when cells create their own steep local gradients by breaking down a prevalent,
Luke Tweedy, Robert H. Insall
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Mitogen Synergy: An Emerging Route to Boosting Human Beta Cell Proliferation
Frontiers in Cell and Developmental Biology, 2022 Decreased number and function of beta cells are a key aspect of diabetes mellitus (diabetes), a disease that remains an onerous global health problem. Means of restoring beta cell mass are urgently being sought as a potential cure for diabetes.
Ekaterina Shcheglova +3 more
doaj +1 more source
JID Innovations, 2022 Psoriasis and atopic dermatitis are chronic inflammatory skin diseases characterized by keratinocyte (KC) hyperproliferation and epidermal acanthosis (hyperplasia).
Hanna Niehues +7 more
doaj +1 more source
Changes in some pro-and anti-inflammatory cytokines produced by bovine peripheral blood mononuclear cells following foot and mouth disease vaccination [PDF]
Archives of Razi Institute, 2016 Interleukin (IL)-17 is exclusively produced by CD4 helper T-cells upon activation. It most often acts as a pro-inflammatory cytokine, which stimulates the release of pro-inflammatory cytokines IL-6, IL-8, TNF-α, and granulocyte-macrophage colony ...
N. Delirezh, R. Norian, A. Azadmehr
doaj +1 more source
Scientific Reports, 2021 The potential to treat diabetes by increasing beta-cell mass is driving a major effort to identify beta-cell mitogens. Demonstration of mitogen activity in human beta cells is frequently performed in ex vivo assays.
Hasna Maachi +3 more
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Commentary: locating the restriction point
Cell Division, 2023 Attempts to map the Restriction Point in the mammalian cell cycle typically involve stimulating quiescent cells with mitogens for increasing intervals, removing the stimulus and then determining the proportion of cells that reach S phase at some point ...
Robert F. Brooks
doaj +1 more source
eLife, 2021 Multiple mitogenic pathways capable of promoting mammalian cardiomyocyte (CM) proliferation have been identified as potential candidates for functional heart repair following myocardial infarction.
Nicholas Strash +5 more
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Mitogen-induced B-cell proliferation activates Chk2-dependent G1/S cell cycle arrest. [PDF]
PLoS ONE, 2014 B-cell activation and proliferation can be induced by a variety of extracellular stimuli. The fate of an activated B cell following mitogen stimulation can be dictated by the strength or duration of the signal, the expression of downstream signaling ...
Pavel A Nikitin +4 more
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