Results 171 to 180 of about 59,323 (260)

Activation of Mitomycin C by NADPH:Cytochrome P-450 Reductase

open access: yes, 1990
Mitomycin C is an alkylating agent used in cancer chemotherapy that shows some specificity towards hypoxic cells. The therapeutic effects of this compound are thought to result from its metabolic activation by enzymes such as NADPHxytochrome P-450 ...
Bartoszek, Agnieszka   +6 more
core  

Organ‐sparing management of luminal gastrointestinal cancers: current and emerging approaches

open access: yesInternal Medicine Journal, Volume 56, Issue 6, Page 958-965, June 2026.
Abstract Treatment of luminal gastrointestinal malignancies with curative intent has traditionally required a combination of systemic treatments and complex surgical resections, which carry risks to function and quality of life. Organ‐sparing approaches to treating gastrointestinal malignancies have advanced significantly.
Cassidy M. Van Stiphout   +9 more
wiley   +1 more source

The In Vitro Wound‐Scratch Assay: Applications, Technical Advances, and Limitations in Wound Healing Research

open access: yesInternational Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT The wound‐scratch assay is a widely used in vitro model for studying collective cell migration, a fundamental process contributing to wound closure and re‐epithelialisation. Owing to its simplicity, low cost, and adaptability, it has become a foundational tool for early‐stage wound‐healing research and therapeutic screening. The assay involves
Philisiwe F. Molefe   +3 more
wiley   +1 more source

Multifunctional Oregano‐Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study

open access: yesInternational Wound Journal, Volume 23, Issue 6, June 2026.
ABSTRACT Chronic wounds, exacerbated by infection, aging, diabetes, and oxidative stress, remain a significant challenge in clinical management and impose a substantial burden on healthcare systems. This study presents oregano‐derived plasma polymers (OPP) as a multifunctional surface coating for advanced wound healing applications.
Jesus Romo‐Rico   +7 more
wiley   +1 more source

Intrahepatic Cholangiocarcinoma: Epidemiological Trends, Risk Factors, Diagnostic Challenges, and Advances in Personalized Therapy—A Comprehensive Review

open access: yesJournal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1701-1721, June 2026.
ABSTRACT Intrahepatic cholangiocarcinoma (iCCA) ranks as the second most common primary liver cancer, compared to about 20% of cases. Its global incidence has climbed over the past four decades, yet early detection remains indefinable due to its asymptomatic nature. Five‐year survival rate of approximately is under 10%.
Yaqoob Muhammad   +10 more
wiley   +1 more source

Extensively and Pan-Drug Resistant Pseudomonas aeruginosa Strains from Burn Patients in Mexico City are Genetically Related to Isolates Recovered a Decade Earlier in Local Hospitals. [PDF]

open access: yesCurr Microbiol
Rojas-Rios R   +7 more
europepmc   +1 more source

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