Results 31 to 40 of about 1,093 (182)
, 1990 The total synthesis of mitomycins via isomitomycin A is described. Key reactions are a Michael-type coupling reaction between chalcone (94)* and 5-ethylthio-2-trimethylsiloxyfuran, followed by an azido-olefin cyclization.
Yang, Lihu
core
Synthesis of indolequinones. New synthetic route to the pyrrolo[1,2- α ]indole ring systems [PDF]
, 1973 The thermal decomposition of 2-azido-3-vinyl-1,4-quinones results in their smooth ring closure to indole-4,7-diones (indolequinones related to the biologically significant mitomycins)
Germeraad, Paul, Moore, Harold W
core +1 more source
, 2022 Mitomycins are a family of naturally occurring, potent alkylating agents in which the C member has been clinically used for cancer chemotherapy for over 5 decades.
Qian Yang (300330) +4 more
core +1 more source
Outcomes and Trends of Anal Squamous Cell Carcinoma in Queensland: A 26‐Year Review
ANZ Journal of Surgery, EarlyView.Anal squamous cell carcinoma incidence and mortality increased substantially in Queensland over 26 years, while survival outcomes remained unchanged. Evolving HPV prevention and screening strategies offer opportunities to reduce future disease burden, but substantial implementation barriers exist.
Amanda G. Liesegang +3 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose This systematic review and meta‐analysis aim to evaluate the efficacy and safety of further lowering intraocular pressure (IOP) to single‐digit levels in treated patients with progressive normal‐tension glaucoma (NTG). Methods A literature search was conducted in MEDLINE (via PubMed), Scopus and Web of Science. We selected studies that
Beatriz Araújo‐Azevedo +2 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose The Baerveldt glaucoma drainage implant (BGI 101–350) is one of the most effective treatment options for managing refractory glaucoma. To mitigate early hypotony in non‐valved implants, intraluminal occluding sutures (IOSs) are commonly used.
Evripidis Sykakis +7 more
wiley +1 more source
FR900482, a close cousin of mitomycin C that exploits mitosene-based DNA cross-linking [PDF]
, 1997 Background: The class of antitumor antibiotics that includes FR900482 has a very close structural analogy to the mitomycins, one of which, mitomycin C, has been in widespread clinical use for more than 20 years.
Rollins, Samuel B. +2 more
core +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To assess the vision‐related quality of life (VRQoL) in glaucoma patients over 5 years after primary Baerveldt glaucoma implant (BGI) or trabeculectomy (TE) using a secondary analysis of a randomized clinical trial. Methods Patients were randomized to undergo TE or receive a BGI.
Ionela Popescu‐Giovanitsas +4 more
wiley +1 more source
Acta Ophthalmologica, EarlyView.Abstract Purpose To evaluate bleb morphology longitudinally using sonography following glaucoma drainage device (GDD) surgery. Methods Prospective observational cohort study conducted from January 2022 to March 2024, with follow‐up up to 12 months postoperatively. Bleb morphology, including superior and inferior bleb height, transverse and longitudinal
Constance Liegl +9 more
wiley +1 more source
Clinical outcomes of the PAUL® glaucoma implant for secondary glaucoma
Acta Ophthalmologica, EarlyView.Abstract Purpose Secondary glaucoma encompasses a broad spectrum of disease entities arising from diverse ocular pathologies and is often refractory to conventional treatment. Glaucoma drainage devices (GDDs) have therefore become an important surgical option.
Carolin Deubel +7 more
wiley +1 more source