Results 81 to 90 of about 7,933 (262)

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Um chamado que ecoa? A representação dos mitos no jogo Call of Cthulhu

Revista de Estudos Literários da UEMS - REVELL, 2019
O presente artigo teve como objeto o jogo Call of Cthulhu, desenvolvido pela Cyanide studios e lançado no dia 30 de Outubro de 2018. Baseado no universo criado por Lovecraft, o jogo narra a jornada de Edward Pierce, um detetive particular contratado ...
Carla Larissa dos Santos de Souza, Ramiro Giroldo   +1 more
doaj  

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

Bioactive Magnesium Silicate Activating Myocardial Energy Metabolism For Infarcted Myocardium Repair

Exploration, EarlyView.
ABSTRACT The heart is a highly energy‐dependent organ, developing bioenergy‐activating biomaterials to activate myocardial adenosine triphosphate (ATP) production and restore dysregulated energy homeostasis is a promising solution for its functional recovery.
Zhibin Liao, Chen Qin, Erhong Song, Chengbin Ding, Zhixu Wang, Yan Sun, Chen Song, Junjie Liu, Jingge Ma, Hongjian Zhang, Leyu Wang, Chengtie Wu   +11 more
wiley   +1 more source

The politics of hero myth in President Jokowi's biopic film (2013)

Satwika: Kajian Ilmu Budaya dan Perubahan Sosial
Among the prominent Indonesian biographical films concerning "national heroes" that emerged in the 2010s is "Jokowi" (2013). This film narrates the life of Joko Widodo (Jokowi), who was then serving as the Governor of Jakarta and was released a month ...
Muhammad Dzaky Abdullah, Ari J. Adipurwawidjana, Muhamad Adji   +2 more
doaj   +1 more source

Combination of Lenvatinib and Antibiotics: A Potential Approach to Enhance Sensitivity in Differentiated Thyroid Cancer

International Journal of Cancer, EarlyView.
Although lenvatinib is the current first‐line therapy for radioiodine‐refractory differentiated thyroid carcinoma, its use is limited by severe side effects and reduced sensitivity. Here, the authors assessed the potential of sensitizing differentiated thyroid carcinoma tumor cells with limited lenvatinib responsiveness through the administration of ...
Celina Ablinger, Petra Huber‐Cantonati, Daniela D. Weber, Sarah Pichler, Georg Schischkow, Marta Garcia‐Miralles, Christian Pirich, Gundula Rendl, Teresa Kiener, Thomas Felder, Martin Geroldinger, Robert Terkola, Barbara Kofler, Johanna Pachmayr   +13 more
wiley   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Factors Impacting Tracheostomy Decisions in Korean Individuals With Amyotrophic Lateral Sclerosis: A Cross‐Sectional Survey

Muscle &Nerve, EarlyView.
ABSTRACT Introduction/Aims Decisions regarding tracheostomy are often made under emergent circumstances, although they require complex considerations of patient preferences, quality of life, and prognosis. This study investigated decision‐making surrounding tracheostomy in Korean people with amyotrophic lateral sclerosis (pwALS) and factors influencing
Juhee Chae, Shin Hye Yoo, Sun Young Lee, Jong‐Su Kim, Jung‐Joon Sung, Seok‐Jin Choi   +5 more
wiley   +1 more source

A good mother of a Chicano family: the everyday practices in the series "Brown Angel Mysteries", by Lucha Corpi

Gragoatá, 2012
Everyday practices are a strong presence in detec­tive series Brown Angel Mysteries, by Chicana writer Lucha Corpi, Based on Michel de Certeau’s theory about everyday practices, developed in The practice of everyday life, this article aims at discussing ...
Carla Portilho
doaj  

Community perceptions and management of the fleshy‐fruited invasive alien plant Pyracantha angustifolia: Insights from South Africa's Montane grasslands

People and Nature, EarlyView.
Abstract Invasive alien plants can provide economic or cultural benefits to local communities, influencing perceptions and potentially affecting management decisions. Understanding these perceptions is crucial to avoiding inefficiencies, misunderstandings and conflicts in the management of invasive alien species.
Lehlohonolo D. Adams, Grant. D. Martin, Sandy‐Lynn Steenhuisen, Colleen T. Downs   +3 more
wiley   +1 more source