Results 121 to 130 of about 380,556 (390)

E3 Ubiquitin Ligase TRIM Proteins, Cell Cycle and Mitosis

Cells, 2019
The cell cycle is a series of events by which cellular components are accurately segregated into daughter cells, principally controlled by the oscillating activities of cyclin-dependent kinases (CDKs) and their co-activators.
Santina Venuto, Giuseppe Merla
doaj   +1 more source

Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. [PDF]

, 2018
Cell division is essential to expand, shape, and replenish epithelia. In the adult small intestine, cells from a common progenitor intermix with other lineages, whereas cell progeny in many other epithelia form contiguous patches.
Castillo-Azofeifa, David, Delling, Markus, Klein, Ophir D, McKinley, Kara L, Royer, Loic A, Schartner, Christoph, Stuurman, Nico, Vale, Ronald D   +7 more
core   +1 more source

Polo‐Like Kinase 1 Phosphorylation Tunes the Functional Viscoelastic Properties of the Centrosome Scaffold

Advanced Science, EarlyView.
To enable mitotic spindle assembly during cell division, centrosomes must bear tensile stresses generated by microtubule‐mediated pulling forces. Micro‐rheology reveals that PLK‐1 phosphorylation of the scaffold protein SPD‐5 tunes the viscoelasticity, size, and morphology of the centrosome scaffold in C. elegans.
Matthew Amato, June Ho Hwang, Manolo U. Rios, Nicole E. Familiari, Michael K. Rosen, Jeffrey B. Woodruff   +5 more
wiley   +1 more source

Deficiency of mastl, a mitotic regulator, results in cell detachment from developing tissues of zebrafish embryos

Frontiers in Cell and Developmental Biology
To form tissues with unique functions and structures, it is important that the cells that comprise them maintain physical contact. On the other hand, with each mitosis, drastic changes in cell shapes, cell adhesion, and cytoskeletal architecture may ...
Hideko Utsumi, Hideko Utsumi, Taijiro Yabe, Taijiro Yabe, Taijiro Yabe, Sumito Koshida, Sumito Koshida, Sumito Koshida, Akira Yamashita, Akira Yamashita, Akira Yamashita, Shinji Takada, Shinji Takada, Shinji Takada   +13 more
doaj   +1 more source

Mitotic antipairing of homologous and sex chromosomes via spatial restriction of two haploid sets. [PDF]

, 2018
Pairing homologous chromosomes is required for recombination. However, in nonmeiotic stages it can lead to detrimental consequences, such as allelic misregulation and genome instability, and is rare in human somatic cells.
Hua, Lisa L, Mikawa, Takashi
core   +1 more source

Cellpose+, a Morphological Analysis Tool for Feature Extraction of Stained Cell Images

Advanced Intelligent Discovery, EarlyView.
We introduce Cellpose plus, a morphological and geometrical analysis tool for feature extraction of stained cell images built over Cellpose, a state‐of‐the‐art cell segmentation framework. We also introduce a dataset of DAPI and FITC stained cells to which our new method is applied.
Israel A. Huaman, Fares D. E. Ghorabe, Sofya S. Chumakova, Alexandra A. Pisarenko, Alexey E. Dudaev, Tatiana G. Volova, Galina A. Ryltseva, Sviatlana A. Ulasevich, Ekaterina I. Shishatskaya, Ekaterina V. Skorb, Pavel S. Zun   +10 more
wiley   +1 more source

Unveiling an Arpp-19 phosphorylation switch that grants chromosome stability

Communications Biology
During cell division, the onset of mitosis is granted by activation of cyclin B-dependent kinase 1 (Cdk1), master mitotic kinase, coordinated with inactivation of Cdk1-counteracting phosphatases.
Angela Flavia Serpico, Caterina Pisauro, Asia Trano, Domenico Grieco   +3 more
doaj   +1 more source

Ki-67 and CDK1 control the dynamic association of nuclear lipids with mitotic chromosomes

Journal of Lipid Research
Nuclear lipids play roles in regulatory processes, such as signaling, transcriptional regulation, and DNA repair. In this report, we demonstrate that nuclear lipids may contribute to Ki-67-regulated chromosome integrity during mitosis.
Hsiao-Tang Hu, Ueh-Ting Tim Wang, Bi-Chang Chen, Yi-Ping Hsueh, Ting-Fang Wang   +4 more
doaj   +1 more source

A simple biophysical model emulates budding yeast chromosome condensation

eLife, 2015
Mitotic chromosomes were one of the first cell biological structures to be described, yet their molecular architecture remains poorly understood. We have devised a simple biophysical model of a 300 kb-long nucleosome chain, the size of a budding yeast ...
Tammy MK Cheng, Sebastian Heeger, Raphaël AG Chaleil, Nik Matthews, Aengus Stewart, Jon Wright, Carmay Lim, Paul A Bates, Frank Uhlmann   +8 more
doaj   +1 more source

Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis

Journal of Cell Biology, 2015
Suspended cells transiently increase their volume during mitosis because of ion exchange through the plasma membrane.
S. Son, J. Kang, Seungeun Oh, M. Kirschner, T. Mitchison, S. Manalis   +5 more
semanticscholar   +1 more source