Non‐invasive papillary urothelial carcinomas with minor high‐grade component are not associated with a more indolent behavior and should likely be regarded as high‐grade carcinomas. Aims The latest WHO edition proposed using a cut‐off of ≥5% high‐grade component (%HGc) as a criterion to label non‐invasive papillary urothelial carcinomas as high‐grade ...
Mina S. Farag +5 more
wiley +1 more source
Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies. [PDF]
Wan Q +6 more
europepmc +1 more source
Ossifying spindled and epithelioid tumour (OSET) can show unusual morphologic features, including minimal or absent peripheral ossification, eosinophil‐rich stroma, increased mitotic activity (≥5 mitotic figures per 10 high‐power fields), and necrosis.
Rayan M Sibira +9 more
wiley +1 more source
HMMR/RHAMM recruits SACK1D/FAM83D-CK1α complex at the mitotic spindle to control spindle alignment. [PDF]
Cartwright TN +7 more
europepmc +1 more source
Duplication of vas genes is universally observed in aphids, and phylogenetic analysis indicates that this event predates the divergence of Aphididae and Phylloxeridae. Ap‐vas1 is germline‐specific, whereas Ap‐vas2–4 exhibit somatic expression, indicating functional divergence during aphid embryogenesis.
Gee‐Way Lin +4 more
wiley +1 more source
Unequal mitochondrial segregation promotes asymmetric fates during neurogenesis. [PDF]
Bunel B +5 more
europepmc +1 more source
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto +14 more
wiley +1 more source
Multi-gradient permutation survival analysis identifies mitosis and immune signatures steadily associated with cancer patient prognosis. [PDF]
Cai X +6 more
europepmc +1 more source
A deep learning–clinical nomogram hybrid for predicting sentinel lymph node metastasis in melanoma
We developed MISSLE, a deep learning–clinical nomogram hybrid model, to predict sentinel lymph node metastasis in invasive cutaneous melanoma with a high area under the receiver operating characteristic curve of 0.950 on the test set. MISSLE identifies key histopathological features and integrates AI for improved clinical decision‐making.
Minh‐Khang Le +8 more
wiley +1 more source
Corrigendum to 'Small-scale siRNA screen reveals WWC2 as a novel regulator of cardiomyocyte mitosis' [Journal of Molecular and Cellular Cardiology 210 (2025) 127-136]. [PDF]
Yücel D +13 more
europepmc +1 more source

