Results 211 to 220 of about 380,556 (390)

Robinow syndrome DVL1 variants disrupt morphogenesis and appendage formation in a Drosophila disease model

Developmental Dynamics, EarlyView.
Abstract Background Robinow syndrome is a rare developmental syndrome caused by variants in genes in Wnt signaling pathways. We previously showed that expression of patient variants in Dishevelled 1 (DVL1) in Drosophila and chicken models disrupts the balance of canonical and non‐canonical Wnt signaling.
Gamze Akarsu, Katja R. MacCharles, Kenneth Kin Lam Wong, Joy M. Richman, Esther M. Verheyen   +4 more
wiley   +1 more source

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Reversible arginine methylation of PI3KC2α controls mitotic spindle dynamics. [PDF]

Cell Commun Signal
Cho Y, Hwang JW, Bedford MT, Na DH, Song DG, Kim SN, Kim YK.   +6 more
europepmc   +1 more source

Critical Evaluation of Methods for the Identification of Aneugens

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT The genotoxic potential of chemicals must be evaluated in regulatory safety assessment settings, including but not limited to, the development of new pharmaceuticals, industrial chemicals, food and cosmetic ingredients, and agrochemicals. Initial assessment of the chromosome‐damaging potential of chemicals is often conducted in mammalian cells
Xiaowen Sun, Stephen D. Dertinger, Azeddine Elhajouji, Daniel J. Roberts, Jan van Benthem, Maik Schuler, Shambhu Roy, Alexandra Taraboletti, Connie L. Chen   +8 more
wiley   +1 more source

A distinct phase of cyclin B (Cdc13) nuclear export at mitotic entry in <i>Schizosaccharomyces pombe</i>. [PDF]

Open Biol
Chethan SG, Rogers JM, Vijayakumari D, Williams W, Gligorovski V, Rahi SJ, Hauf S.   +6 more
europepmc   +1 more source

Evidence for the Occurrence of True Mitosis in Bacteria and Certain Applications1

, 1952
Edward D. DeLamater
openalex   +1 more source

Mitosis in Trichomonas [PDF]

Proceedings of the National Academy of Sciences, 1915
Olive Swezy, Charles A. Kofoid
openaire   +2 more sources

TUBA1A‐related tubulinopathy associated with the infantile epileptic spasms syndrome and atypical absence seizures

Epileptic Disorders, EarlyView.
Abstract Patients with TUBA1A pathogenic variants may present with complex brain malformation, intellectual disability, and epilepsy. The epilepsy phenotype is varied, ranging from mild to severe, with epileptic spasms and focal seizures being the most common seizure types.
Andy Cheuk‐Him Ng, Morris H. Scantlebury   +1 more
wiley   +1 more source

Chromosome Structure and Behavior in Mitosis and Meiosis

, 1935
Hally Jolivette Sax, Karl Sax
openalex   +1 more source

Target Binding of Black Phosphorus Nanomaterial to Polo‐Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein

Exploration, EarlyView.
This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Fangfang Liu, Zhong‐Da Li, Yanqiao Zeng, Xiaofeng Wang, Yingnan Liu, Qi Li, Wenhe Luo, Xiaoman Suo, Yaqing Xu, Feng Yuan, Dan Zhang, Wuqiong Zhang, Shengyong Geng, Xue‐Feng Yu, Guofang Zhang, Yang Li   +15 more
wiley   +1 more source