Results 31 to 40 of about 29,600 (205)

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Repair of Double Orifice Left AV Valve (DOLAVV) with Endocardial Cushion Defect in Adult

Brazilian Journal of Cardiovascular Surgery
Double orifice left atrioventricular valve (DOLAVV) or double orifice mitral valve (DOMV) is a rare congenital cardiac anomaly manifesting either as an isolated lesion (mitral stenosis or mitral insufficiency) or in association with other congenital ...
Vivek Velayudhan Pillai, Jayakumar Karunakaran   +1 more
doaj   +1 more source

Implantable Systems for Cardiovascular Treatment and Monitoring: Comparative Insights From Intracardiovascular and Extracardiovascular Technologies

Advanced Intelligent Systems, EarlyView.
A unifying device–cardiovascular interface framework is presented to classify implantable cardiovascular technologies as intracardiovascular blood‐contacting systems or extracardiovascular tissue‐only and blood‐handling architectures. Cross‐class comparison across shared semiquantitative criteria, including blood‐contact burden, biomimicry ...
Bergo Nicolò, Semproni Federica, Maselli Martina, Colli Andrea, Cianchetti Matteo, Ciuti Gastone, Stefanini Cesare, Menciassi Arianna   +7 more
wiley   +1 more source

Surgical Reconstruction of Mitral Restenosis Complicated by a Critically Small Left Ventricular Cavity and Giant Left and Right Atriomegaly (Clinical Case)

Український журнал серцево-судинної хірургії, 2023
Background. Comprehensive reconstruction of the left and right parts of the heart in giant left atriomegaly, adequate tactics of mitral valve replacement in case of concomitant tricuspid insufficiency and dilation of the right atrium lead to an ...
Volodymyr V. Popov, Oleksandr O. Bolshak, Valery Zh. Boukarim, Olena V. Khoroshkovata, Oleksii M. Gurtovenko, Kateryna V. Pukas   +5 more
doaj   +1 more source

Longitudinal Echocardiographic Surveillance of Aortic Dilation in a Phenotype‐Enriched Turner Syndrome Cohort

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Turner syndrome (TS) is associated with thoracic aortopathy and increased risk for aortic dissection, yet the natural history of aortic dilation is not well understood. We performed a retrospective longitudinal study of individuals with TS who participated in the TS Society of the United States Healthy Heart Project between 2003 and 2023 ...
Dylan Doerner, Matthew R. Johnson, Sara Mansoorshahi, Rakesh Kathiresan, Katelyn Abel, Jonathan G. You, Emilio Quezada, Siddharth K. Prakash   +7 more
wiley   +1 more source

Reparo endovascular de válvula mitral con MitraClip®

Revista Colombiana de Cardiología, 2019
Resumen: La insuficiencia mitral severa es una entidad de alta prevalencia cuyo tratamiento de elección es quirúrgico. Sin embargo, la mayoría de veces una gran población no es intervenida por el alto riesgo quirúrgico.
Luis Miguel Benítez, Carlos Alberto Náder, Antonio José Lores, Ángela María Rodríguez, Jairo Cadena, Ángela María Cucalón, Mauricio Zúñiga, Camilo Arana, Antonio Enrique Dáger, Jaime Andrés Fonseca   +9 more
doaj   +1 more source

Student engagement in the anatomical sciences: What gets in the way?

Anatomical Sciences Education, EarlyView.
Abstract Active learning has become central to anatomical sciences education, yet its effectiveness largely depends on student engagement. Here we define the anatomical sciences as gross anatomy, surface anatomy, neuroanatomy, embryology, histology, and integrated radiology.
Kasidy K. Dobish, Kathryn B. Moore, Danielle M. Delucchi, Stephen L. Jenkins, Geoffrey T. Dorius, David A. Morton   +5 more
wiley   +1 more source

Comparative treatment effects of direct oral anticoagulants versus warfarin for nonvalvular atrial fibrillation in clinical practice vary over time due to channelling

British Journal of Clinical Pharmacology, EarlyView.
Aim Temporal shifts in patient characteristics can influence comparative treatment effects within a certain indication. We investigated patient characteristics and comparative effectiveness and safety for direct oral anticoagulants (DOACs) and warfarin over the time period where DOACs replaced warfarin as preferred stroke prophylaxis in patients with ...
Raoul B. L. J. van den Hemel, Aernoud T. L. Fiolet, Magdalena A. Gamba, Patrick C. Souverein, Olaf H. Klungel, Lourens T. Bloem, Sophie H. Bots   +6 more
wiley   +1 more source

Electrical Storm Triggered by Conus Branch Occlusion During Elective Percutaneous Coronary Intervention in Very Severe Aortic Stenosis: Rescue With Balloon Aortic Valvuloplasty Under Venoarterial Extracorporeal Membrane Oxygenation

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT We report a case of very severe aortic stenosis (AS) in which side‐branch occlusion during elective percutaneous coronary intervention (PCI) precipitated life‐threatening ventricular arrhythmias and hemodynamic collapse. The patient was a 72‐year‐old man with very severe AS who was scheduled to undergo a valve intervention.
Taiki Kodama, Nobuhiro Honda, Saya Hiromatsu, Seigo Masuda   +3 more
wiley   +1 more source

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source