Results 91 to 100 of about 28,644 (225)

Prediabetic cardiomyopathy is attenuated by hypothalamic PVN oxytocin neuron activation

The Journal of Physiology, EarlyView.
Abstract figure legend A long‐term high‐fat, high‐fructose diet induces prediabetes with insulin resistance, hyperinsulinaemia, elevated triglycerides and metabolic‐associated steatotic liver disease (MASLD) in male rats. Animals developed prediabetic cardiomyopathy characterized by diastolic dysfunction, interstitial fibrosis and tachycardia ...
Anna Nilsson, Joan Escobar, Kira Kuraoka, Ian Venter, Cielo A. Carnate, Matthew W. Kay, David Mendelowitz, Kathryn J. Schunke   +7 more
wiley   +1 more source

Best treatment option for secondary mitral regurgitation surgery: a network meta-analysis of randomized and non-randomized controlled studies

Scientific Reports
The objective of this study is to ascertain whether subvalvular papillary muscle repair in conjunction with restrictive mitral valve annuloplasty represents the most efficacious treatment for patients presenting with secondary ischemic mitral ...
Francesco Nappi, Antonio Salsano, Arnaldo Dimagli, Francesco Santini, IvanCarmine Gambardella, Omar Ellouze   +5 more
doaj   +1 more source

Percutaneous Mitral Valve Repair for Mitral Regurgitation

Journal of Interventional Cardiology, 2003
Mitral regurgitation (MR) associated with, ischemic, and degenerative (prolapse) disease, contributes to left ventricular (LV) dysfunction due to remodeling, and LV dilation, resulting in worsening of MR. Mitral valve (MV) surgical repair has provided improvement in survival, LV function and symptoms, especially when performed early.
openaire   +2 more sources

Acute intermittent hypercapnic hypoxia augments left ventricular contractility

The Journal of Physiology, EarlyView.
Abstract figure legend Twenty‐four healthy adults were studied to determine the effects of an acute session of 40 min of intermittent hypercapnic hypoxia on cardiac performance. Cardiac function was assessed via echocardiography at rest and during graded stages of lower‐body negative pressure before and after the intervention to quantify load ...
Scott F. Thrall, Alex M. Williams, Philip J. Millar, Megan L. Lance, Brooke M. Shafer, Conan L. H. Shing, Jordan D. Bird, Christopher R. West, Glen E. Foster   +8 more
wiley   +1 more source

Angiotensin‐converting enzyme and exercise adaptations: Genetic variability, pharmacological modulation and future directions

The Journal of Physiology, EarlyView.
Abstract figure legend ACE I/D genotype, enzyme activity and integrated physiological adaptations. Upper panel: Conceptual framework linking the ACE I/D polymorphism (left) with circulating/tissue ACE activity (centre; violin plots based on hypothetical data for illustration) and strength/power versus endurance phenotypes (right).
Tórur Sjúrðarson, Nikolai B. Nordsborg   +1 more
wiley   +1 more source

Pushing boundaries in cardiac surgery: minimally invasive mitral valve repair combined with tricuspid valve repair and/or other concomitant procedures

Frontiers in Cardiovascular Medicine
IntroductionMinimally invasive mitral valve repair/replacement has emerged as a widely accepted surgical approach for managing mitral valve disorders.
Marie-Elisabeth Stelzmueller, Robert Zilberszac, Raphael Rosenhek, Doris Hutschala, Sabine Kappel, Andrea Lassnig, Guenther Laufer, Daniel Zimpfer, Wilfried Wisser   +8 more
doaj   +1 more source

4D ultrasound reveals regional left atrial strain remodelling in a murine model of reversible pressure overload

The Journal of Physiology, EarlyView.
Abstract figure legend Traditional planar imaging approaches of the left atrium do not capture complex geometry. Four‐dimensional imaging allows the acquisition of 3D data + time to visualize left atrial geometry and kinematics. We designed an advanced analysis technique to investigate left atrial biomechanics in a model of pressure overload and ...
John P. Salvas, Thomas Moore‐Morris, Craig J. Goergen, Pierre Sicard   +3 more
wiley   +1 more source

Comparative multimodal calibration of patient‐specific atrial fibrillation models: Impact of imaging and electrophysiology data on arrhythmogenic substrate identification

The Journal of Physiology, EarlyView.
Abstract figure legend Comparative multimodal calibration of patient‐specific left atrial (LA) models to identify arrhythmogenic substrates in atrial fibrillation (AF). A, LA models shown in posterior and anterior views, calibrated separately using: late gadolinium enhancement magnetic resonance imaging (LGE‐MRI) image intensity ratio (IIR; blue–red ...
Mahmoud Ehnesh, Haseeb Valli, Ovais A. Jaffery, Sam Coveney, Alexander Zolotarev, Zhong Chen, Wajid Hussain, David G. Jones, Raad Mohiaddin, Tom Wong, Gregory Slabaugh, Steven A. Niederer, Edward Vigmond, Shouvik Haldar, Caroline Roney   +14 more
wiley   +1 more source

Congenital heart disease in pregnancy and severe maternal morbidity: A distributed data network study

Pregnancy, Volume 2, Issue 5, September 2026.
Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to demonstrate the utility of distributed data networks for obstetric research ...
Elizabeth B. Sherwin, Benjamin Martin, Xiao Xu, Anna Booman, Alyssa Howren, Kimberlee McKay, Sadaf Kazi, Sean O'Reilly, Katie S. Kolla, Khyzer Aziz, Katherine Bianco, Stephanie A. Leonard   +11 more
wiley   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, Volume 73, Issue 8, August 2026.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source