Results 91 to 100 of about 23,995,861 (305)

Stifling silos: The need for a more holistic approach to mixed migration in a warming world [PDF]

, 2021
A climate-changed world is one of mixed migration taking place across a spectrum of time, space, and agency, with both positive and negative outcomes.
Zickgraf, Caroline
core  

Allometric relationships between total height and diameter for volume estimation of bottomland hardwood oaks in Arkansas

Frontiers in Forests and Global Change
Bottomland hardwood (BLH) forests are a unique ecosystem that plays an important role in the provision of ecosystem services, both ecologically and economically. This study modeled allometric relationships between total tree height and diameter at breast
Satish Bhatt, Nana Tian, Yuhui Weng, Douglas Osborne, Jianbang Gan   +4 more
doaj   +1 more source

Cross-validation for nonlinear mixed effects models

Journal of Pharmacokinetics and Pharmacodynamics, 2013
Cross-validation is frequently used for model selection in a variety of applications. However, it is difficult to apply cross-validation to mixed effects models (including nonlinear mixed effects models or NLME models) due to the fact that cross-validation requires “out-of-sample” predictions of the outcome variable, which cannot be easily calculated ...
Colby, Emily, Bair, Eric
openaire   +4 more sources

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Baseline facial emotion recognition is associated with clinical decline across the Alzheimer’s disease spectrum: a multi-instrument longitudinal assessment study

Frontiers in Aging Neuroscience
BackgroundFacial emotion recognition (FER) is increasingly recognized as a functionally relevant domain in the Alzheimer’s disease (AD) spectrum, yet whether baseline FER is associated with subsequent clinical decline remains insufficiently established ...
YongSoo Shim, Eun Ye Lim
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Low Hyperopic Spherical Equivalent and Peripapillary Retinal Nerve Fiber Layer Thickness: A Quadrant-specific Mixed-effects Analysis

Current Medical Issues
Background: Refractive status is known to influence optical coherence tomography (OCT) measurements of the peripapillary retinal nerve fiber layer (RNFL). This pilot study aimed to evaluate the association between low hyperopic spherical refractive error
Sehrish Deva, Iqra Ali, Razia Amin
doaj   +1 more source

Linear Mixed-Effects Models in chemistry: A tutorial [PDF]

Analytica Chimica Acta
A common goal in chemistry is to study the relationship between a measured signal and the variability of certain factors. To this end, researchers often use Design of Experiment to decide which experiments to conduct and (Multiple) Linear Regression, and/or Analysis of Variance to analyze the collected data. Among the assumptions to the very foundation
Andrea Junior Carnoli, Petra oude Lohuis, Lutgarde M.C. Buydens, Gerjen H. Tinnevelt, Jeroen J. Jansen   +4 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

MIXNO: a computer program for mixed-effects nominal logistic regression [PDF]

MIXNO provides maximum marginal likelihood estimates for mixed-effects nominal logistic regression analysis. These models can be used for analysis of correlated nominal response data, for example, data arising from a clustered or longitudinal design. For
Donald Hedeker
core