Results 141 to 150 of about 3,064,383 (240)

A Nonparametric Approach to Practical Identifiability of Nonlinear Mixed Effects Models. [PDF]

Bull Math Biol
Cassidy T, Johnston ST, Plank M, Botha I, Flegg JA, Murphy RJ, Hamis S.   +6 more
europepmc   +1 more source

lmerSeq: an R package for analyzing transformed RNA-Seq data with linear mixed effects models. [PDF]

BMC Bioinformatics, 2022
Vestal BE, Wynn E, Moore CM.
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Bayesian Variable Selection and Estimation in Semiparametric Simplex Mixed-Effects Models with Longitudinal Proportional Data. [PDF]

Entropy (Basel), 2022
Tang A, Duan X, Zhao Y.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Joint mixed-effects models for causal inference in clustered network-based observational studies. [PDF]

Stat Methods Med Res
McNealis V, Moodie EE, Dean N.
europepmc   +1 more source

Assessing Effect of Rootstock Micropropagation on Field Performance of Grafted Peach Varieties by Fitting Mixed-Effects Models: A Longitudinal Study. [PDF]

Plants (Basel), 2023
Marín JA, García E, Lorente P, Andreu P, Arbeloa A.   +4 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

A Step-by-Step Workflow for Performing In Silico Clinical Trials With Nonlinear Mixed Effects Models. [PDF]

CPT Pharmacometrics Syst Pharmacol
Cortés-Ríos J, Magee M, Sher A, Jusko WJ, Desikan R.   +4 more
europepmc   +1 more source

SAMBA: A novel method for fast automatic model building in nonlinear mixed-effects models. [PDF]

CPT Pharmacometrics Syst Pharmacol, 2022
Prague M, Lavielle M.
europepmc   +1 more source