Towards contextualising mixed-use in South Africa [PDF]
The development of mixed-use precincts is an age old idea in the context of Europe and America, but a reasonably new notion in the developing country of South Africa.
Anja, Bredell
core
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
MIXED-USE SAFETY ON RURAL FACILITIES IN THE PACIFIC NORTHWEST: Consideration of Vehicular, Non-Traditional, and Non-Motorized Users [PDF]
In the United States, one in 12 households do not own a personal automobile and approximately 13% of those who are old enough to drive do not. Trips by these individuals are being made in one of many other possible modes, creating the need to “share ...
Belz, Nathan, Chang, Kevin
core
Roadmap to Gridlock: The Failure of Long-Range Metropolitan Transportation Planning [PDF]
Federal law requires metropolitan planning organizations in urban areas of more than 50,000 people to write long-range (20- to 30- year) metropolitan transportation plans and to revise or update those plans every 4 to 5 years.
Randal O'Toole
core +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Towards contextualising mixed-use in South Africa [PDF]
The development of mixed-use precincts is an age old idea in the context of Europe and America, but a reasonably new notion in the developing country of South Africa.
Anja Bredell
core
Fiscal federalism and fiscal autonomy : lessons for the UK from other industrialised countries [PDF]
The purpose of this article is the following. First, we provide a comparison of the degree of fiscal decentralisation in the UK with that in other countries, and assess the extent to which different areas of public expenditure are assigned to different ...
Darby, Julia +2 more
core +3 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The Impact of Built Environment on Mixed Land Use: Evidence from Xi’an
Mixed land use is recognized as a crucial strategy for enhancing urban vitality and promoting urban renewal. While existing research has mainly focused on measuring mixed land use along single dimensions, there remains a notable gap in studies that ...
Jianwei Li +3 more
doaj +1 more source
Background Alongside a recent revival in the use of psychedelics in clinical settings, there have been increases in the prevalence of recreational use, with many using psychedelics to deal with difficult emotions or to improve well-being.
Madelene Palmer, Olivia M. Maynard
doaj +1 more source

