Results 101 to 110 of about 4,572,954 (287)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A study of ontogenetic level of language development and gender differences affecting language use in Acehnese language

open access: yesStudies in English Language and Education, 2017
There have been numerous studies analysing gender differences in language use. Most of them predominantly adopted static or hierarchical approach with obsolete understanding of gender differences.
Muhammad Aulia
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

The Impact of Built Environment on Mixed Land Use: Evidence from Xi’an

open access: yesLand
Mixed land use is recognized as a crucial strategy for enhancing urban vitality and promoting urban renewal. While existing research has mainly focused on measuring mixed land use along single dimensions, there remains a notable gap in studies that ...
Jianwei Li   +3 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

Aquaculture Asia, Vol. 11, No. 4, pp.1-34, October - December 2006 [PDF]

open access: yes, 2006
Rural aquaculture: recent developments in Chinese inland aquaculture, by Peter Edwards. Reducing feed costs in aquaculture: is the use of mixed feeding schedules the answer for semi-intensive practices? by Sena S.

core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Adaptive reuse for sustainable urban development: vertical farming in former department stores. German case study

open access: yesFrontiers in Built Environment
Since digitalization has changed people’s shopping behavior, department stores have partly become obsolete. Concepts for adaptive reuse can help avoid future vacancies or counteract existing ones.
Hanna Bonekämper, Hanna Bonekämper
doaj   +1 more source

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