Results 101 to 110 of about 4,578,897 (287)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Evaluating the challenges and impacts of mixed-use neighborhoods on urban planning: an empirical study of a megacity, Karachi, Pakistan

Discover Sustainability
Introduction Modern development is patented by rapid urbanization, which largely negatively affects the quality of life. Over the past few decades in the World; in the field of urban planning and the real estate market, Mixed-use development has become a
Anila Kausar, Salman Zubair, Hadeeqa Sohail, Muhammad Mushahid Anwar, Asad Aziz, Sergij Vambol, Viola Vambol, Nadeem A. Khan, Serhii Poteriaiko, Vasyl Tyshchenko, Rustam Murasov, Fizza Ejaz, Owais Iqbal Khan   +12 more
doaj   +1 more source

Kensington Courts: a mixed use commercial development

, 1983
Bibliography: p. [1-2].
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

A study of ontogenetic level of language development and gender differences affecting language use in Acehnese language

Studies in English Language and Education, 2017
There have been numerous studies analysing gender differences in language use. Most of them predominantly adopted static or hierarchical approach with obsolete understanding of gender differences.
Muhammad Aulia
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The Impact of Built Environment on Mixed Land Use: Evidence from Xi’an

Land
Mixed land use is recognized as a crucial strategy for enhancing urban vitality and promoting urban renewal. While existing research has mainly focused on measuring mixed land use along single dimensions, there remains a notable gap in studies that ...
Jianwei Li, Yun Chen, Dan Zhao, Jiagang Zhai   +3 more
doaj   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Assessment of Urban Districts in Terms of their Compliance with Public Transport Based Development Principles; The Case of Tehran Kooy-e Nasr District [PDF]

صفه, 2017
In recent years urban development approaches based on public transport (Transit-Oriented Development) have attracted attentions. Despite the emphasis on the term ‘public transport’, rapid transport systems and their proximity alone is not enough. In this
Mahya Azadi, Shahabodin Kermanshahi, Maryam Momeni   +2 more
doaj