Results 171 to 180 of about 4,572,954 (287)

Evaluation of the Metaverse for Teaching and Learning Pharmacology: A Mixed-Method Study. [PDF]

Adv Med Educ Pract
Alhusban A, Alzoubi KH.
europepmc   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

On Mixed Use in Swedish detailed Development Plans

, 2004
The study is based on a programme of research into functionintegrated city environments. In-depth case studies have beencarried out on two planning projects in Karlstad andVästerås. The object of these case studies wasexplorative, the intention being to develop a clear idea of theconditions for function integration and how these aremanifested in ...
openaire   +1 more source

Walking experience in mixed use developments in Lagos, Nigeria

A/Z : ITU journal of Faculty of Architecture, 2021
Adedapo Adewunmi Oluwatayo, Funmi Akande, Ohuntoluwase Oliyide, Ajibola Agbola, Bolaji Aderemi-Lateef, Titilope Samuel   +5 more
openaire   +1 more source

Learning components for mixed reality mass casualty incident training: a modified Delphi study. [PDF]

BMC Med Educ
Gyllencreutz L, Pusa S, Baxter R.
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Barriers and facilitators to implementing the living guideline development framework in oncology: a mixed methods study. [PDF]

BMJ Open
Ismaila N, Harvey BE, Einhaus K, Mbuagbaw L, Ma J, Thabane L.   +5 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Minimally invasive orthodontic management: a paradigm shift in interceptive care. Part I - concept and palatally displaced canines. [PDF]

Dental Press J Orthod
Garib D, Conti ACCF, Miranda F, Massaro C, Sassaki S, Bellini-Pereira SA, Albergaria C.   +6 more
europepmc   +1 more source