Results 231 to 240 of about 4,578,897 (287)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Holding on or heading up? The roosting preferences of brown- and white-feathered laying hen pullets. [PDF]

Poult Sci
Penney M, Harlander A, Sandilands V, Siegford J, Widowski T.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Moving forward, leaving the patients behind? A multilevel assessment framework for evaluating patient-centred, integrated care quality. [PDF]

Qual Life Res
Cassidy S, Lintvedt O, Odeh F, Granja C, Solvoll T.   +4 more
europepmc   +1 more source

Spectacular Twisted Mixed-Use Development Resembles Kaleidoscope with Lumiflon

Focus on Powder Coatings, 2019
openaire   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Non-right-handedness and psychiatric disorders: A synthesis of epidemiological, genetic, and neurobiological evidence. [PDF]

World J Psychiatry
Wang QQ, Sun ZS, Wang JS.
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Integrating qualitative insights with large secondary data: a protocol for a community-engaged mixed-methods study on adolescent substance use. [PDF]

Front Public Health
Silmi KP, Adkins-Jackson P, Meléndrez B, Dang N, Zeray S, Cardenas-Iniguez C, Pugh E, Perez Y, Cervantes N, Peters P, Hammonds S, Covarrubias Reyna I, Álvarez D, Arias M, Murillo J, Gonzalez M.   +15 more
europepmc   +1 more source