Results 61 to 70 of about 4,572,954 (287)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Sharing Qualitative and Qualitative Longitudinal Data in the UK: Archiving Strategies and Development [PDF]
, 2011 Over the past two decades significant developments have occurred in the archiving of qualitative data in the UK. The first national archive for qualitative resources, Qualidata, was established in 1994.
Bishop, Libby, Neale, Bren
core
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Developer-Planner Interaction in Transportation and Land Use Sustainability, MTI Report 01-21 [PDF]
, 2002 This study argues that significant unmet demand exists for alternatives to conventional auto-oriented development; and further that planning interventions that restrict densities and land use mixing in developed areas are a major reason that this demand ...
Inam, Aseem
core +2 more sources
Impact of the surrounding built environment on energy consumption in mixed-use building [PDF]
, 2018 While a mixture of residential and non-residential uses in urban development has advantages in reducing transportation energy consumption and improving efficiency of land utilization, the patterns of energy consumption in mixed-use buildings are largely ...
Choi +3 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Scientific Reports, 2023 The urban development of China is changing from incremental expansion to stock renewal mode. The study of urban functional areas has become one of the important fundamental works in current urban renewal and high-quality urban development.
Minrui Zheng +3 more
doaj +1 more source
Towards contextualising mixed-use in South Africa [PDF]
, 2013 The development of mixed-use precincts is an age old idea in the context of Europe and America, but a reasonably new notion in the developing country of South Africa.
Anja Bredell
core
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Conceptualisations of sustainable tourism development: an examination of the distance between ideology and local desires [PDF]
, 2008 This research seeks to resolve academic concern for the limited insight within existing bodies of knowledge in terms of how Sustainability and Sustainable Tourism Development is conceptualised at a grassroots level; by the stakeholders and more ...
Taylor, F
core