Results 81 to 90 of about 4,578,897 (287)
Morphological design control for large-scale city development: A new proposal [PDF]
, 2011 Whereas many good examples can be found of the study of urban morphology informing the design of new residential areas in Europe, it is much more difficult to find examples relating to other land uses and outside of Europe.
Hall, Tony, Sanders, Paul
core +2 more sources
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Re-Imagining High-Density Mixed-Use Streets
Proceedings of the International Conference of Contemporary Affairs in Architecture and Urbanism-ICCAUAThis paper analyses the essential role of mixed-use streets in contemporary cities and addresses their inherent issues. The study highlights the national policy focus on mixed-use streets, which can improve sustainability, economic development, social ...
Somi Sareen, Mazharul Haque
doaj +1 more source
, 2005 Purpose - This article aims to investigate how R&D employees use their social networks to acquire user information and how this information is used in the development of new products.
Björk, Jennie +2 more
core +2 more sources
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Prediction of the functional properties of ceramic materials from composition using artificial neural networks [PDF]
, 2007 We describe the development of artificial neural networks (ANN) for the prediction of the properties of ceramic materials. The ceramics studied here include polycrystalline, inorganic, non-metallic materials and are investigated on the basis of their ...
Alford, N. Mc N. +4 more
core +2 more sources
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Urban Planning, 2019 Interest in the role of large urban development (LUD) projects in regeneration efforts of cities has risen in recent years. Studies of their planning process have often focused on global cities, examining challenges associated with their joint (public ...
Eran Weinberg +2 more
doaj +1 more source