Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Mixed boundary-value problems for motion equations of a viscoelastic medium
Electronic Journal of Differential Equations, 2015 We study the mixed boundary-value problem for steady motion equations of an incompressible viscoelastic medium of Jeffreys type in a fixed three-dimensional domain.
Mikhail A. Artemov +1 more
doaj
Results in Physics, 2016 This paper investigates the effects of heat and mass transfer in the mixed convection flow of an Oldroyd-B fluid over a stretching surface with convective boundary conditions. Emphasis is given to the analysis of Soret and Dufour effects.
M. Bilal Ashraf +3 more
doaj +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
On the Volterra property of a boundary problem with integral gluing condition for a mixed parabolic-hyperbolic equation [PDF]
, 2013 Abdumauvlen Berdyshev +3 more
openalex +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A posteriori error estimates for the generalized overlapping domain decomposition method for a parabolic variational equation with mixed boundary condition [PDF]
, 2019 Salah Boulaaras +2 more
openalex +1 more source
Adaptive Boundary Element for the Problem with Mixed Boundary Condition.
TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series A, 1995 This paper concerns a construction of adaptive boundary elements for the two-dimensional problems with mixed boundary conditions such as heat transfer condition between heated body surface and surrounding medium. The scheme is an extension of the method proposed by the present authors, called sample point error analysis and related error indicator for ...
Norio Kamiya, Yuji Aikawa, Ken Kawaguchi
openaire +2 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source