Results 141 to 150 of about 691,938 (340)

Existence, and Ulam's types stability of higher-order fractional Langevin equations on a star graph

open access: yesAIMS Mathematics
A study was conducted on the existence of solutions for a class of nonlinear Caputo type higher-order fractional Langevin equations with mixed boundary conditions on a star graph with $ k+1 $ nodes and $ k $ edges.
Gang Chen, Jinbo Ni, Xinyu Fu
doaj   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

High-order mixed-type differential equations with weighted integral boundary conditions

open access: yesElectronic Journal of Differential Equations, 2000
In this paper, we prove the existence and uniqueness of strong solutions for high-order mixed-type problems with weighted integral boundary conditions. The proof uses energy inequalities and the density of the range of the operator generated.
M. Denche, A. L. Marhoune
doaj  

Study of singular elliptic equations with mixed boundary conditions and nonlocal source terms

open access: yesElectronic Journal of Qualitative Theory of Differential Equations
In this article, we study the generalized solutions for singular elliptic equations with mixed boundary conditions, a nonlocal source term and a Hardy potential.
Khaled Kefi   +2 more
doaj   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

open access: yesFEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq   +3 more
wiley   +1 more source

To a nonlocal generalization of the Dirichlet problem

open access: yesJournal of Inequalities and Applications, 2006
A mixed problem with a boundary Dirichlet condition and nonlocal integral condition is considered for a two-dimensional elliptic equation.The existence and uniqueness of a weak solution of this problem are proved in a weighted Sobolev space.
Berikelashvili Givi
doaj  

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