Results 71 to 80 of about 691,938 (340)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Nonlinear and oblique boundary value problems for the Stokes equations

Electronic Journal of Qualitative Theory of Differential Equations, 2011
In this paper we consider the nonlinear boundary value problem governed by a stationary perturbed Stokes system with mixed boundary conditions (Dirichlet- maximal monotone graph), in a smooth domain.
Hamid Benseridi, Mourad Dilmi
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Problems with Mixed Boundary Conditions in Banach Spaces [PDF]

Chinese Journal of Mathematics, 2017
Using Leray-Schauder degree or degree for α-condensing maps we obtain the existence of at least one solution for the boundary value problem of the following type: φu′′=ft,u,u′,  u(T)=0=u′(0), where φ:X→X is a homeomorphism with reverse Lipschitz constant such that φ(0)=0, f:0,T×X×X→X is a continuous function, T is a positive real number, and X is a ...
openaire   +2 more sources

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Fourth-Order Approximation of the Fundamental Matrix of Linear System of Differential Equations

Sultan Qaboos University Journal for Science, 1997
A fourth-order approximation to the fundamental matrix of a system of linear differential equations is presented in closed form as a matrix exponential.
A.M. Hussein
doaj   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

A Boundary Integral Equation with the Generalized Neumann Kernel for a Certain Class of Mixed Boundary Value Problem

Journal of Applied Mathematics, 2012
We present a uniquely solvable boundary integral equation with the generalized Neumann kernel for solving two-dimensional Laplace’s equation on multiply connected regions with mixed boundary condition.
Mohamed M. S. Nasser, Ali H. M. Murid, Samer A. A. Al-Hatemi   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Similarity solution of mixed convective boundary layer slip flow over a vertical plate

Ain Shams Engineering Journal, 2013
Effects of slip at the boundary on the mixed convective boundary layer flow over a flat plate are investigated. Similarity transformations are employed to transform the governing partial differential equations into ordinary ones, which are then solved ...
Krishnendu Bhattacharyya, Swati Mukhopadhyay, G.C. Layek   +2 more
doaj   +1 more source