Results 131 to 140 of about 443,069 (407)

Associations between circulating endostatin levels and vascular organ damage in systemic sclerosis and mixed connective tissue disease: an observational study

Arthritis Research & Therapy, 2015
IntroductionSystemic sclerosis (SSc) and mixed connective tissue disease (MCTD) are chronic immune-mediated disorders complicated by vascular organ damage.
S. Reiseter, Ø. Molberg, R. Gunnarsson, M. Lund, T. Aaløkken, P. Aukrust, T. Ueland, T. Garen, C. Brunborg, A. Michelsen, Aurelija Abraityte, A. Hoffmann-Vold   +11 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Rituximab compared to intravenous cyclophosphamide in adults with connective tissue disease-associated interstitial lung disease: the RECITAL RCT [PDF]

BACKGROUND: Interstitial lung disease frequently complicates systemic autoimmune disorders including scleroderma, idiopathic inflammatory myositis and mixed connective tissue disease, resulting in considerable morbidity and mortality.
Ashby, Deborah, Denton, Christopher P, Fletcher, Sophie V, Fordham, Richard J, Gibbons, Michael, Grossi Sampedro, Carlota, Hoyles, Rachel K, Kokosi, Maria, Maher, Toby M, Molyneaux, Philip L, Parfrey, Helen, Renzoni, Elisabetta A, Saunders, Peter, Szigeti, Matyas, Tudor, Veronica A, Wells, Athol U, Xydopoulos, Georgios, Zanghelini, Fernando   +17 more
core  

TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT) [PDF]

, 2005
Background: Fibroblastic foci are characteristic features in lung parenchyma of patients with idiopathic pulmonary fibrosis (IPF). They comprise aggregates of mesenchymal cells which underlie sites of unresolved epithelial injury and are associated with ...
A Atfi, A Desmouliere, A Desmouliere, CM Ewing, D Upadhyay, DA Vesey, DG. Hoyt, DW Powell, DW Powell, DY Rhyu, E Healy, E Piek, EE Moussad, EP Bottinger, F Strutz, G Raghu, GR Grotendorst, HW Yao, J Fan, J Gauldie, J Nightingale, J Yang, JT Allen, JT Allen, K Vleminckx, KA Foster, LH Pan, M Kelly, M Selman, M Selman, M Whitman, N Khalil, N Khalil, N Khalil, NA Bhowmick, NA Wahab, NA Wahab, NA Wahab, P Bonniaud, P Sharmila, PJ Miettinen, PJ Sime, R Derynck, R Kalluri, S Hashimoto, T Maeyama, TE King Jr, TJ Gross, V Mermall, Y Higashimoto, Y Liu   +50 more
core   +4 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

The association between muscle strength and activity limitations in patients with the hypermobility type of Ehlers–Danlos syndrome : the impact of proprioception [PDF]

, 2016
Purpose: The patients diagnosed with Ehlers-Danlos Syndrome Hypermobility Type (EDS-HT) are characterized by pain, proprioceptive inacuity, muscle weakness, potentially leading to activity limitations.
Calders, Patrick, de Vries, Janneke, De Wandele, Inge, Engelbert, Raoul, Malfait, Fransiska, Rombaut, Lies, Scheper, Mark, van der Esch, Martin, Visser, Bart   +8 more
core   +2 more sources

Siblings with mixed connective tissue disease.

Nihon Naika Gakkai Zasshi, 1987
膠原病での家族内発症の報告は散見されるが,混合性結合組織病(mixed connective tissue disease, MCTD)での家族内発症は極めてまれである.我々は, MCTDを発症した姉妹例を経験した.妹は,レイノー現象,手指硬化症,多関節炎,拘束性換気障害,白血球減少,血小板減少, CK値上昇,抗RNP抗体陽性であった.姉は,レイノー現象,手指硬化症,肺線維症,筋力低下,白血球減少,血小板減少, CK値上昇,抗RNP抗体陽性であった.姉妹ともに厚生省MCTD研究班の診断の手引きに合致しており, MCTDと診断し得た.姉妹のHLA抗原の分析では,共通してAw24, B7, Cw7, DR1抗原を有していた.かかる症例は ...
Terufumi Fukui, Hirobumi Kondou, Sadao Kashiwazaki   +2 more
openaire   +3 more sources

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

A genome-wide association study identifies four novel susceptibility loci underlying inguinal hernia. [PDF]

, 2015
Inguinal hernia repair is one of the most commonly performed operations in the world, yet little is known about the genetic mechanisms that predispose individuals to develop inguinal hernias.
Ahituv, Nadav, Avins, Andrew, Chen, David C, Eckalbar, Walter L, Hinds, David, Jorgenson, Eric, Makki, Nadja, Shen, Ling, Tian, Chao   +8 more
core   +2 more sources

Barriers and facilitators for mental healthcare in pediatric lupus and mixed connective tissue disease: a qualitative study of youth and parent perspectives

Pediatric Rheumatology Online Journal, 2015
BackgroundUntreated mental health problems may result in poor outcomes for youth with systemic lupus erythematosus (SLE) and mixed connective tissue disease (MCTD).
A. Knight, M. Vickery, A. Fiks, F. Barg
semanticscholar   +1 more source