Results 141 to 150 of about 443,069 (407)

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Pleura: In connective tissue diseases

The Journal of Association of Chest Physicians, 2016
Connective tissue diseases (CTDs) (or collagen vascular diseases) represent a heterogeneous group of immunologically mediated disorders that affects many organs of the body including pleura.
Kaushik Saha
doaj   +1 more source

The arthritis of mixed connective tissue disease. [PDF]

, 1978
Robert M. Bennett, Denis J. O'Connell
openalex   +1 more source

Mixed connective tissue disease: To be or not to be? [PDF]

Arthritis & Rheumatism, 1998
Josef S. Smolen, Günter Steiner
openaire   +3 more sources

Depression and anxiety and their association with healthcare utilization in pediatric lupus and mixed connective tissue disease patients: a cross-sectional study

Pediatric Rheumatology Online Journal, 2014
BackgroundDepression and anxiety adversely affects outcomes in systemic lupus erythematosus (SLE) and healthcare utilization is high for pediatric SLE.
A. Knight, P. Weiss, K. Morales, M. Gerdes, Allyson Gutstein, M. Vickery, R. Keren   +6 more
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]

, 2016
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M, Llado, A, Paolino, S, Pizzorni, C, Ruaro, B, Smith, Vanessa, Sulli, A   +6 more
core   +1 more source

Proteasome alpha-type subunit C9 is a primary target of autoantibodies in sera of patients with myositis and systemic lupus erythematosus [PDF]

, 1996
Autoantibodies occur in low frequencies among patients with myositis characterizing only distinct subsets of this disease. Most of these known antibodies are directed to enzymatically active complexes.
Burmester, G.R., Doerner, T., Feist, E., Hiepe, F., Kloetzel, P.M., Kuckelkorn, U., Micheel, B., Schmidtke, G.   +7 more
core   +1 more source

Artificial intelligence-enabled precision medicine for inflammatory skin diseases [PDF]

arXiv
Recent advances in artificial intelligence (AI) and multimodal data collection are revolutionizing dermatology. Generative AI and machine learning approaches offer opportunities to enhance the diagnosis and treatment of inflammatory skin diseases, including atopic dermatitis, psoriasis, hidradenitis suppurativa, and autoimmune connective tissue disease.
arxiv  

Mutilans‐like arthropathy in mixed connective tissue disease [PDF]

, 1979
D Alarcón-Segovia, Oscar Uribe‐Uribe
openalex   +1 more source