Results 141 to 150 of about 143,917 (257)

Environmental Determinants of Surgical Site Infections in Abdominal Surgeries: A Scoping Review of Evidence from East Africa

open access: yesJournal of Multidisciplinary Healthcare
Alphonsine Imanishimwe,1,2 Celestin Banamwana,1 Georges Bucyibaruta,3,4 Christian Nsanzabaganwa,5 Faustin Ntirenganya,2,4 Erigene Rutayisire1 1School of Public Health, College of Medicine and Health Sciences, University of Rwanda, Kigali, Rwanda; 2Global
Imanishimwe A   +5 more
doaj  

External immune sentinels in the seawater ecosystem: the specialization of bivalve hemocytes. [PDF]

open access: yesFront Immunol
Rey-Campos M   +6 more
europepmc   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

open access: yesAdvanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang   +11 more
wiley   +1 more source

The effect of different surface treatment on shear bond strength of soft and hard liners to CAD-CAM and conventional denture base resins: <i>in vitro</i> comparative study. [PDF]

open access: yesFront Dent Med
Albazroun Z   +9 more
europepmc   +1 more source

Pathogenic Role of FGFR3 Autoantibodies in Small Fiber Neuropathy

open access: yesAdvanced Science, EarlyView.
Autoantibodies against fibroblast growth factor receptor 3 (FGFR3) are identified as pathogenic drivers of pain in small fiber neuropathy. By binding to sensory neurons in dorsal root ganglia, FGFR3 autoantibodies activate MAPK signaling and induce hyperexcitability and mechanical hypersensitivity, establishing FGFR3 autoantibodies as a therapeutic ...
Lyuba Y. Salih   +12 more
wiley   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

open access: yesAdvanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel   +19 more
wiley   +1 more source

Inhibition of SLC11A1‐Mediated Lysosomal Iron Accumulation in Microglia Promotes Repair Following White Matter Stroke

open access: yesAdvanced Science, EarlyView.
Genetic and pharmacological inhibition of SLC11A1 functioning as an H+/Fe2+ antiporter–mediated lysosomal iron accumulation in microglia promotes lysosomal lumen acidification, increases CTSD expression, enhances lysosomal myelin debris uptake and degradation, and promotes repair following white matter stroke. ABSTRACT White matter stroke (WMS) results
Lingling Qiu   +11 more
wiley   +1 more source

Porcine salivary carbonic anhydrase VI is involved in the pathogenesis of disease. [PDF]

open access: yesFront Vet Sci
Matas-Quintanilla M   +3 more
europepmc   +1 more source

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