Results 171 to 180 of about 23,995,846 (308)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Longitudinal trajectories and predictors of glycated hemoglobin among type 2 diabetes patients concomitant with hypertension: spline based linear mixed-effects model. [PDF]

Sci Rep
Simegn MB, Feleke HG, Baylie T, Mazengia EM, Mengie MG, Endalew B, Aschale A, Birhanu KD, Agedew E, Dugassa KT, Geremew H, Kebie AB, Tilahun WM.   +12 more
europepmc   +1 more source

Is Social Support Associated with Colorectal Cancer Care Utilization? A Multilevel Mixed-Effects Model of a Cross-Sectional Cohort Study in Vietnam. [PDF]

Asian Pac J Cancer Prev, 2023
Le DD, Tran TB, Nguyen GT, Nguyen TM, Tran TXM, Nguyen LHT, Dang NTT, Vo TV, Sarakarn P.   +8 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Review no. 2: a beginner's guide for calculating eGFR slope using linear mixed-effects model in R-step-by-step methods and code examples. [PDF]

Clin Exp Nephrol
Oshima M, Gosho M, Iwagami M, Sugawara Y, Nagasu H, Kuwabara T, Sofue T, Nakagawa N, Miyamoto Y.   +8 more
europepmc   +1 more source

Stochastic Expectation Maximization Algorithm for Linear Mixed-Effects Model with Interactions in the Presence of Incomplete Data. [PDF]

Entropy (Basel), 2023
Zakkour A, Perret C, Slaoui Y.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

The Impact of Sociodemographic Factors on Job Insecurity Among Obstetric Nurses Under the Low Fertility Background: A Linear Mixed-Effects Model Analysis and Targeted Intervention Strategies. [PDF]

J Multidiscip Healthc
Chen D, Ma J.
europepmc   +1 more source

Mixed-effects model: a useful statistical tool for longitudinal and cluster studies. [PDF]

J Bras Pneumol, 2023
Silveira LTYD, Ferreira JC, Patino CM, Patino CM.   +3 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source