Results 81 to 90 of about 34,540 (263)

Consistent Estimation of a Mixing Distribution

The Annals of Statistics, 1992
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openaire   +3 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Mixed membership estimation for social networks

Journal of Econometrics
84 ...
Jin, Jiashun, Ke, Zheng Tracy, Luo, Shengming   +2 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

On the Estimation of Mixing Distributions

The Annals of Mathematical Statistics, 1966
Let $\mathscr{F} = \{F(x; y), y \varepsilon E\}$ be a family of cumulative distribution functions (cdf's) in the variable $x$ indexed by $y \varepsilon E$, where $E$ is a measurable subset of the real line. Assume that $F(x; y)$ is measurable in $y$ for all $x$.
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Nonparametric Density Estimation in a Mixed Model Using Wavelets

Axioms
This paper investigates nonparametric estimations of a density function within a mixed density model. A linear wavelet density estimator and an adaptive nonlinear wavelet estimator are proposed using wavelet method and hard thresholding algorithm.
Dan Liang, Junke Kou
doaj   +1 more source

Multiple Estimation Architecture in Discrete-Time Adaptive Mixing Control

Machines, 2013
Adaptive mixing control (AMC) is a recently developed control scheme for uncertain plants, where the control action coming from a bank of precomputed controller is mixed based on the parameter estimates generated by an on-line parameter estimator.
Simone Baldi
doaj   +1 more source

Drift Estimation Under Strong Mixing

, 1994
It is shown that a kernel-type estimate for the drift function is pointwise as well as uniformly strongly consistent, under strong mixing condition.
Arfi, Mounir, Lecoutre, Jean-Pierre
openaire   +2 more sources