Results 111 to 120 of about 969,174 (273)

Samuelson´s full duality and the use of directed acyclical graphs [PDF]

To date, mixed demand systems have been all but ignored in empirical work. A possible reason for the scarcity of such applications is that one needs to know a priori which prices and quantities are endogenous in the mixed demand system.
David A. Bessler, Matthew C. Stockton, Oral Capps Jr.   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Graph Convolutional Network with Sequential Attention for Goal-Oriented Dialogue Systems

Transactions of the Association for Computational Linguistics, 2019
Domain-specific goal-oriented dialogue systems typically require modeling three types of inputs, namely, (i) the knowledge-base associated with the domain, (ii) the history of the conversation, which is a sequence of utterances, and (iii) the current ...
Banerjee, Suman, Khapra, Mitesh M.
doaj   +1 more source

Colored Homomorphisms of Colored Mixed Graphs

Journal of Combinatorial Theory, Series B, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Nešetřil, Jaroslav, Raspaud, André
openaire   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Path-driven orientation of mixed graphs

Discrete Applied Mathematics, 2015
We consider in this paper two graph orientation problems. The input of both problems is (i) a mixed graph G whose vertex set is V and edge set (resp. arc set) is E (resp. A) and (ii) a set P V V of source-target pairs. The first problem, called S-GO, is a decision problem introduced by Hassin and Megiddo (Linear Algebra and its Applications 114 (1989):
Fertin, Guillaume, Mohamed-Babou, Hafedh, Rusu, Irena   +2 more
openaire   +3 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Imbalanced graph learning via mixed entropy minimization

Scientific Reports
Imbalanced datasets, where the minority class is underrepresented, pose significant challenges for node classification in graph learning. Traditional methods often address this issue through synthetic oversampling techniques for the minority class, which
Liwen Xu, Huaguang Zhu, Jiali Chen
doaj   +1 more source