Results 61 to 70 of about 750,885 (330)

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Marine Heatwaves/Cold‐Spells Associated With Mixed Layer Depth Variation Globally

Geophysical Research Letters
Marine heatwaves (MHWs) and cold‐spells (MCSs) are extreme sea surface temperature events with significant impacts on marine ecosystems. However, the connection between these events and mixed layer depth (MLD) variations, as well as how their intensity ...
Wenjin Sun, Yindi Wang, Yifei Yang, Jingsong Yang, Jinlin Ji, Changming Dong   +5 more
doaj   +1 more source

Variability of currents and mixing processes during the onset of the equatorial cold tongue in the Atlantic [PDF]

, 2012
The heat content of the surface water masses is important for the circulation of the oceans and the atmosphere. The surface layer serves as a medium for the ocean-atmosphere exchange and thereby significantly affects the dynamics of our climate.
Milinski, Sebastian
core  

An Argo mixed layer climatology and database [PDF]

, 2017
Author Posting. © American Geophysical Union, 2017. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution.
Gilson, John, Holte, James, Roemmich, Dean, Talley, Lynne D.   +3 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Spatial and seasonal variability of the air-sea equilibration timescale of carbon dioxide [PDF]

, 2014
The exchange of carbon dioxide between the ocean and the atmosphere tends to bring waters within the mixed layer toward equilibrium by reducing the partial pressure gradient across the air-water interface.
, Antonov, Broecker, Daniel C. Jones, Dickson, Ekman, Emerson, England, Garcia, Gent, Gill, Goswami, Gruber, Ho, Holte, Ito, Ito, Ito, Kalnay, Khatiwala, Khoo, Large, Lee, Lee, Liss, Locarnini, Marshall, Marshall, Mazloff, McGillis, Millero, Millero, Milliff, Nightingale, Ohno, Peng, Risien, Roemmich, Sabine, Sallée, Sarmiento, Sweeney, Takahashi, Takamitsu Ito, Toggweiler, Toggweiler, Wanninkhof, Wanninkhof, Watson, Wei-Ching Hsu, Wunsch, Yohei Takano   +51 more
core   +1 more source

Estimating Mixed Layer Depth from Oceanic Profile Data

Journal of Atmospheric and Oceanic Technology, 2003
Abstract Estimates of mixed layer depth are important to a wide variety of oceanic investigations including upper-ocean productivity, air–sea exchange processes, and long-term climate change. In the absence of direct turbulent dissipation measurements, mixed layer depth is commonly derived from oceanic profile data using threshold, integral, least ...
Richard E. Thomson, Isaac V. Fine
openaire   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Evaluating CMIP5 simulations of mixed layer depth during summer [PDF]

Journal of Geophysical Research: Oceans, 2014
The ability of CMIP5 models in simulating surface mixed layer depth (MLD) during summer is assessed using 45 climate models. Their ocean models differ greatly in terms of vertical mixing parameterizations and model configurations. In some models, effects of surface waves, Langmuir circulations, submesoscale eddies, as well as additional wind mixing are
Chuan Jiang Huang, Fangli Qiao, Dejun Dai   +2 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source