Results 141 to 150 of about 658,858 (308)

Locally Ideal Formulations for Piecewise Linear Functions with Indicator Variables

, 2013
In this paper, we consider mixed integer linear programming (MIP) formulations for piecewise linear functions (PLFs) that are evaluated when an indicator variable is turned on.
Linderoth, Jeff, James Luedtke, Luedtke, Jim, Luedtke, James, Sridhar, Srikrishna, Srikrishna Sridhar, Jeff Linderoth   +6 more
core  

Gilmour's approach to mixed and stochastic restricted ridge predictions in linear mixed models

, 2016
This article is concerned with the predictions in linear mixed models under stochastic linear restrictions. Mixed and stochastic restricted ridge predictors are introduced by using Gilmour's approach.
Kuran Ö., Özkale M.R.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

MCMC Methods for Multi-Response Generalized Linear Mixed Models: The MCMCglmm R Package

Generalized linear mixed models provide a flexible framework for modeling a range of data, although with non-Gaussian response variables the likelihood cannot be obtained in closed form.
Jarrod D. Hadfield
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Methodological implementation of mixed linear models in multi-locus genome-wide association studies. [PDF]

Brief Bioinform, 2018
Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R.   +9 more
europepmc   +1 more source

Linear mixed effect models.

, 2016
Linear mixed effect models.
Irina Vakoliuk (2864987), Elena Platonova (2864981), Vaidas Palinauskas (214364), Dmitry Kobylkov (2864984), Gediminas Valkiūnas (214333), Andrey Mukhin (3150585)   +5 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Applications of linear mixed models in Cynodon spp. breeding

Crop Breeding and Applied Biotechnology
Species of the genus Cynodon are among the most cultivated forage crops in the world due to their high yield and nutritional quality, and its use in cattle feeding has been associated with gains in animal weight and increased milk production.
Arthur Mayrink Elizeu, Marco Antônio Peixoto, Jeniffer Santana Pinto Coelho Evangelista, Saulo Fabrício da Silva Chaves, Emanuel Ferrari Nascimento, Flávio Benites, Paulo Eduardo Teodoro, Kaio Olimpio das Gracas Dias, Leonardo Lopes Bhering   +8 more
doaj  

Methodological implementation of mixed linear models in multi-locus genome-wide association studies. [PDF]

Brief Bioinform, 2017
Wen YJ, Zhang H, Ni YL, Huang B, Zhang J, Feng JY, Wang SB, Dunwell JM, Zhang YM, Wu R.   +9 more
europepmc   +1 more source