Results 71 to 80 of about 320,563 (285)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Double layer mixed matrix membrane adsorbers improving capacity and safety hemodialysis [PDF]

, 2018
Double layer mixed matrix membranes adsorbers have been developed for blood toxin removal by embedding activated carbon into cellulose acetate macroporous membranes.
Z. Borneman, Saiful, Borneman, Z Zandrie, M. Wessling, Wessling, Matthias Matthias, Borneman, Zandrie, Saiful, S, Borneman, Z., Wessling, M., Wessling, Matthias, null Saiful   +10 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Tailoring CO2 /CH4 separation properties of mixed-matrix membranes via combined use of two- and three-dimensional metal-organic frameworks

, 2018
Mixed-matrix membranes containing both two-dimensional (ns-CuBDC) and three-dimensional (ZIF-8) metal-organic frameworks were fabricated to investigate their potential capabilities in CO2/CH4 separation.
Yang, Yanqin, Yanqin Yang, Samarasinghe, S. A. S. C., Chong Yang Chuah, S.A.S.C. Samarasinghe, Tae-Hyun Bae, Samarasinghe, S.A.S.C., Bae, Tae-Hyun, Chuah, Chong Yang   +8 more
core   +1 more source

Metal-organic framework based mixed matrix hydrogel membranes for highly efficient gas separation

Advanced Membranes, 2021
MOF/polymer interface in mixed-matrix membranes (MMMs) has been considered as a crucial issue for achieving highly efficient gas separation performance.
Lei Tian, Yuxiu Sun, Xiangyu Guo, Zhihua Qiao, Chongli Zhong   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Long-Term Stable Metal Organic Framework (MOF) Based Mixed Matrix Membranes for Ultrafiltration

, 2020
In this study, novel mixed matrix polyethersulfone (PES) membranes were synthesized by using two different kinds of metal organic frameworks (MOFs), namely UiO-66 and UiO-66-NH2.
Shanxue, Jiang, Kaisong, Zhang, Bradley P., Ladewig, Stefan J. D., Smith, Huanting, Wang, Muayad, Al-shaeli   +5 more
core   +1 more source

Preparation of Pebax 1657/MAF-7 Mixed Matrix Membranes with Enhanced CO₂/N₂ Separation by Active Site of Triazole Ligand

Membranes, 2022
Fillers play a critical role in the performance of mixed matrix membranes (MMMs). Microporous metal azolate frameworks (MAFs) are a subclass material of metal–organic frameworks (MOFs). Due to the uncoordinated nitrogen of the organic ligands, MAF-7 (SOD-
Xingqian Wang, Yuping Zhang, Xinwei Chen, Yifei Wang, Mingliang He, Yongjiang Shan, Yuqin Li, Fei Zhang, Xiangshu Chen, Hidetoshi Kita   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source