RIPK4 function interferes with melanoma cell adhesion and metastasis
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Determination of Interface Fracture Parameters in Thermoplastic Fiber Metal Laminates Under Mixed-Mode I+II. [PDF]
Smolnicki M, Duda S.
europepmc +1 more source
A Phase Field Approach to Two-Dimensional Quasicrystals with Mixed Mode Cracks. [PDF]
Li T, Yang Z, Xu C, Xu X, Zhou Z.
europepmc +1 more source
Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini +2 more
wiley +1 more source
Formulation of low temperature mixed mode crack propagation behavior of crumb rubber modified HMA using artificial intelligence. [PDF]
Ghafari S +4 more
europepmc +1 more source
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
Efficient removal of antibody aggregates using TOYOPEARL MX-Trp-650M mixed-mode resin under salt or pH gradient elution. [PDF]
Zhang J, Zhang P, Li Y.
europepmc +1 more source
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani +7 more
wiley +1 more source
Study of Influence of Mixed-Mode Solar Drying on Chlorophyll, Ascorbic Acid, Carotenoid, and Antioxidant Activity of Medicinal Leaves of Ageratina Variety pichinchensis. [PDF]
Guillén-Velázquez P +4 more
europepmc +1 more source

