Results 181 to 190 of about 1,828,929 (311)

Analyzing childhood (0-59 months) malnutrition determinants in five West African countries of Gabon, Gambia, Liberia, Mauritania, and Nigeria using a generalized additive mixed model from DHS data. [PDF]

Front Nutr
Beni R, Ramroop S, Habyarimana F.
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A scalable variational inference approach for increased mixed-model association power. [PDF]

Nat Genet
Loya H, Kalantzis G, Cooper F, Palamara PF.   +3 more
europepmc   +1 more source

K-PD Modeling of Plozasiran - Mixed Hyperlipidemia

Nathalie Gosselin, Jack Shi
openalex   +1 more source

Sex-stratified linear mixed models: Non-binary traits (Item 3/3)

, 2021
Elena Bernabeu, Oriol Canela‐Xandri, Konrad Rawlik, Albert Tenesa   +3 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

An integer programming approach to mixed model assembly line balancing.

, 1981
Mehmet Melih. Akgun
openalex   +1 more source

Diagnostic analytics for the mixed Poisson INGARCH model with applications

Wenjun Dang, Fukang Zhu, Nuo Xu, Shuangzhe Liu   +3 more
openalex   +2 more sources

An approach to chaos in some mixed p-spin models [PDF]

, 2012
Wei‐Kuo Chen, Dmitry Panchenko
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source