Results 221 to 230 of about 12,789,297 (308)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Flexible and efficient count-distribution and mixed-model methods for eQTL mapping with quasar

Pullin JM, Choi J, Choi J, McCarthy DJ, Wallace C.   +4 more
europepmc   +1 more source

ZIBGLMM: Zero-inflated bivariate generalized linear mixed model for meta-analysis with double-zero-event studies. [PDF]

Res Synth Methods
Li L, Lin L, Cappelleri JC, Chu H, Chen Y.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Acute Decrease in Glenohumeral Internal Rotation During Repetitive Baseball Pitching Is Associated with Transient Structural Changes in Medial Longitudinal Arch of Stride Leg: Pilot Study Using Mixed Model. [PDF]

Sports (Basel)
Abekura T, Maeda N, Tashiro T, Arima S, Kaizuka R, Koyanagi M, Iwata K, Yoshida H, Ito G, Ueda M, Yamada T.   +10 more
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Correction: Spatial-temporal patterns and predictors of timing and inadequate antenatal care utilization in Zambia: A Generalized Linear Mixed Model (GLMM) investigation from 1992 to 2018. [PDF]

PLOS Glob Public Health
Shumba S, Fwemba I, Kaymba V.
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Unveiling Diverse Trajectories of Internet Addiction and the Influence of Family Environment and Obsessive Beliefs: Multi-Wave Longitudinal Study With Growth Mixed Model. [PDF]

J Med Internet Res
Tan C, Pu W, Mo Q, Wang X, Xiang Y, Chen S, Xu C, Zhang Y, Zhang J.   +8 more
europepmc   +1 more source