Results 121 to 130 of about 1,513,668 (313)

Factor analytic multiplicative mixed models in the analysis of multiple experiments [PDF]

, 2004
Analysis of groups of experiments or multi-environment trials (MET) has been traditionally based on simple models assuming error variance homogeneity between trials, independent error within trials, genotype x environment (g x e) effects as a set of ...
De Resende, M. D. V., Thompson, R.
core  

Genetic divergence and parent selection of sugarcane clones

Crop Breeding and Applied Biotechnology, 2008
The objective of this study was to estimate the genetic divergence of 140 sugarcane clones of the series RB97, in phase T3 of the Sugarcane Genetic Improvement Program of the Universidade Federal do Paraná, at three locations by multivariate analysis ...
Valéria Rosa Lopes, João Carlos Bespalhok Filho, Ricardo Augusto de Oliveira, Edson Perez Guerra, José Luís Camargo Zambon, Edelclaiton Daros   +5 more
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Estimation and prediction of parameters and breeding values in soybean using REML/BLUP and Least Squares

Crop Breeding and Applied Biotechnology, 2008
The aim of this study was to compare REML/BLUP and Least Square procedures in the prediction and estimation of genetic parameters and breeding values in soybean progenies, F>.; and F 4.5 progenies were evaluated in the 2005/06 growing season and the Fy.4
Agnaldo Donizete Ferreira de Carvalho, Roberto Fritsche Neto, Isaias Olívio Geraldi   +2 more
doaj  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Be-Breeder: an R/Shiny application for phenotypic data analyses in plant breeding

Crop Breeding and Applied Biotechnology, 2018
In order to successfully achieve the final goal of genotype selection in plant breeding programs, many aspects must be considered and carefully thought regarding cost, time, and efficiency.
Filipe Inácio Matias, Italo Granato, Roberto Fritsche-Neto   +2 more
doaj  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Generalized Additive Modelling of Mixed Distribution Markov Models with Application to Melbourne's Rainfall. [PDF]

We consider modelling time series using a generalized additive model with first- order Markov structure and mixed transition density having a discrete component at zero and a continuous component with positive sample space.
Hyndman, R.J., Grunwald, G.K.
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source